雄激素受体在Her-2过表达型乳腺癌中的表达及其临床意义

Expression and clinical significance of androgen receptor in human epidermal growth factor receptor-2 enrich breast cancer

目的:探讨雄激素受体(androgen receptor,AR)在人类表皮生长因子受体-2(human epidermal growth factor receptor-2,Her-2)过表达型乳腺癌中的表达及其与临床病理特征的关系。方法 :免疫组化检测AR在102例Her-2过表达型乳腺癌的表达情况,并分析其与Her-2过表达型乳腺癌临床病理特征的相关性。结果:AR在Her-2过表达型乳腺癌阳性率为75.5%;AR阳性Her-2过表达型乳腺癌患者的淋巴结转移率及Ki-67阳性率较低(P<0.05);AR表达在年龄、绝经状态、肿瘤大小、组织学分级、脉管癌栓、p53及PCNA是否阳性差异均无统计学意义(P>0.05)。结论:AR在Her-2过表达型乳腺癌中的表达率高;AR可能是Her-2过表达型乳腺癌潜在治疗靶点。

Objective To investigate the expression of AR and its relationship with clinicopathological features in human epidermal growth factor receptor-2（Her-2） enrich breast cancer. Mehtods The expression of AR was detected by immunohistochemical staining in 102 patients with Her-2 enrich breast cancer. The relationship between AR expression and its clinicopathological characteristics was analyzed. Results The positive rate of AR expression was 75.5%. Patients in the positive group had a lower level of lymph nodes and Ki-67 value（P 〈 0.05）. However, no significant differences of AR expression were observed in age, menopausal status, tumor size, histological grade, vessel invasion, P53 and PCNA（P 〉 0.05）. Conclusion AR was highly expressed in Her-2 enrich breast cancer, which may be a potential target for treatment of Her-2 enrich breast cancer.