灯盏花素注射液对急性脑梗死患者血液生化指标和血液流变学的影响

Effects of Breviscapine Injection on Blood Biochemical Indexes and Hemorheology Indexes in Patients with Acute Cerebral Infarction

目的:探讨灯盏花素注射液对急性脑梗死患者血清肽素(Copeptin)、N端前脑钠肽(NT-pro BNP)、缺血修饰白蛋白(IMA)水平和血液流变学的影响。方法:回顾性收集132例急性脑梗死患者资料,按照治疗方法的不同分为观察组(66例)和对照组(66例)。对照组患者给予阿司匹林肠溶片1片,qd+肌氨肽苷注射液20 ml加入500 ml 0.9%氯化钠溶液中静脉滴注,qd+奥扎格雷钠注射液4 ml加入250 ml 0.9%氯化钠溶液中静脉滴注,qd;观察组患者在对照组治疗的基础上加用灯盏花素注射液5 ml加入250ml 0.9%氯化钠溶液中静脉滴注,qd。7 d为1个疗程,两组均治疗2个疗程。考察两组患者治疗前后Copeptin、NT-proBNP、IMA水平[以血清钴结合白蛋白(ACB)值表示]和相关血液流变学指标变化情况。结果:治疗前,两组患者Copeptin、NT-proBNP、血清ACB值、全血黏度、血浆黏度、血细胞比容、血细胞沉降率和纤维蛋白原水平比较差异均无统计学意义(P>0.05);治疗后,两组患者Copeptin、NT-proBNP、全血黏度、血浆黏度、血细胞比容、血细胞沉降率和纤维蛋白原水平显著低于同组治疗前,且观察组低于对照组,而血清ACB值显著高于同组治疗前,且观察组高于对照组,差异均有统计学意义(P<0.05)。结论:在常规治疗基础上加用灯盏花素注射液可以显著降低急性脑梗死患者Copeptin、NT-proBNP、IMA水平,改善血液流变性。

OBJECTIVE： To observe the effects of Breviscapine injection on serum copeptin, NT-proBNP and ischemia modi- fied albumin （IMA） level and hemorheology indexes in patients with acute cerebral infarction. METHODS： Data of 132 patients with acute cerebral infarction were selected and randomly divided into observation group （66 cases） and control group （66 cases）. Control group received 1 Aspirin enteric-coated tablet, qd ＋ 20 ml Muscular amino acids and nucleosides injection adding into 500 ml 0.9% Sodium chloride solution, intravenous infusion, qd ＋ 4 ml Ozagrel injection adding into 250 ml Sodium chloride solution, intravenous infusion, qd. Observation group was additionally given 5 ml Breviscapine injection adding into 250 ml 0.9% Sodium chloride solution, intravenous infusion, qd. 7 d ag was regarded as 1 treatment course, it lasted for 2 courses. Copeptin, NT-proB- NP, IMA levels （showed by serum ACB value） and changes of related hemorheology indexes before and after treatment in 2 groups were observed. RESULTS： Before treatment, there was no significant difference in Copeptin, NT-proBNP, serum ACB val- ue, whole blood viscosity, plasma viscosity, hematocrit, ESR and fibrinogen levels in 2 groups（P〉0.05） ; after treatment, Co- peptin, NT-proBNP, whole blood viscosity, plasma viscosity, hematocrit, ESR and fibrinogen levels in 2 groups were significant- ly lower than before, and observation group was lower than control group, while serum ACB value was significantly higher than be- fore, and observation group was significantly higher than control group, the differences were statistically significant（P〈0.05）. CONCLUSIONS： Based on conventional treatment, Breviscapine injection can significantly improve the copeptin, NT-proBNp and IMA levels, and improve hemorrheology.