“H型”高血压患者同型半胱氨酸与血糖、血脂和肾功能的相关性研究

Correlation study between the level of serum homocysteine in patients with H type hypertension and blood glucose,blood lipid and renal function

目的探讨"H型"高血压患者血清同型半胱氨酸(Hcy)水平与部分血液生化指标的相关性。方法 109例明确诊断"H型"高血压患者,记录一般资料、血清Hcy、空腹血糖(GL.U)、糖化血红蛋白(HbA1c)、血清肌酐(Cr)、肌酐清除率(Ccr)、血尿素氮(BUN)、血尿酸(UA)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)及低密度脂蛋白(LDL-C)水平并进行分析。结果不同Hcy水平组之间GLU、HbA1c、Cr、Ccr、BUN、HDL-C、LDL-C相比,组间存在差异(P<0.05)。不同Hcy水平组之间的性别、年龄、高血压病程、既往脑卒中、吸烟史、饮酒史、脑卒中家族史、体质指数(BMI)、TG、TC相比,差异无统计学意义。结论在血脂、血糖和肾功能方面,"H型"高血压患者Hcy水平与部分血液生化指标存在相关性。

Objective To analyze the relationship between the level of serum homocysteine in patients with H type hypertension and serum biochemical indicators. Methods One hundred nine patients with H type hypertension were enrolled. The general conditions, the level of serumhomocysteine, GLU, HbAlc, Cr, Ccr, BUN, UA, TG, TC, HDL-C, LDL- C were analyzed. Result There were significant differences in GLU, HbA1C, Cr, Ccr, BUN, HDL-C, LDL-C between different levels of serum homocysteine. There were no correlation between the level of serum homocysteine and gender, age, duration of hypertension, previous stroke, smoking history, drinking history, family history of stroke, BMI, TG, TC. Conclusion In the respect of the blood glucose, blood lipid and renal function, there is relationship between the level of Hcy and a part of biochemical indicators in patients with H type hypertension.