新疆地区汉族和维吾尔族146例白塞病的临床特点分析

Clinical characteristics analysis of 146 Han and the Uyghur cases with Behcet＇s disease in Xinjiang Uygur Autonomous region

目的探讨新疆地区白塞病患者的特点。方法回顾分析了新疆维吾尔自治区人民医院146例被确诊为白塞病的住院患者，分析了其人口参数及临床表现。采用检验矿检验和Fisher确切概率法行统计分析。结果①146例白塞病患者中，99例汉族，47例维吾尔族。口腔溃疡146例（100％）；生殖器溃疡115例（78．8％），其中汉族76例（76．8％），维吾尔族39例（82．9％），两者比较差异无统计学意义（P=0.391）。以口腔溃疡起病83例（56．8％），其中汉族60例（60．6％），维吾尔族23例（48．9％）；其次口腔溃疡和生殖器溃疡起病同时起病42例（28．8％），汉族23例（23．2％），维吾尔族19例（40．4％），两者比较汉族口腔和生殖器溃疡同时起病高于维吾尔族（P=0.032）。②皮肤损害66例（45．2％），其中汉族45例（45．4％），维吾尔族21例（44．7％），两者比较差异无统计学意义（P=0.930）。③关节受累40例（27．4％），其中汉族22例（22．2％），维吾尔族18例（38．3％），两者比较汉族关节受累高于维音尔族（P=0．042）。④眼部受累21例（14．4％），其中汉族9例（9．1％），维吾尔族12例（25．5％），两者比较维吾尔族眼部受累高于汉族（P=0．008）。⑤血管病变8例（5．5％），汉族5例（5％），维吾尔族各3例（6．4％），两者比较差异无统计学意义（P=0.712）。⑥神经系统病变2例（1．37％），汉族和维吾尔族各1例，两者比较差异无统计学意义（P=0.542）。结论新疆地区白塞病患者临床表现的常见部位和起病部位同样是口、生殖器，常见部位依次还可累及皮肤、关节、眼部、血管、神经系统，其中汉族关节受累高于维吾尔族，维吾尔族眼部受累高于汉族；起病部位中汉族口腔和生殖器溃疡同时起病高于维吾尔族。

Objective To discuss the characteristics of in-patients with Behqers disease in Xinjiang Uygur Autonomous region. Methods Clinical data of 146 cases with Behcers disease admitted to Xinjiang Uygur Autonomous region people＇s hospital were analyzed. The demographic data and clinical manifestations were analyzed retrospectively. The categorical data was compared using X2 test or Fisher＇s exact test. Results ① Of the 146 patients with BD, 99 cases were Hart, 47 cases were uyghurs. Oral ulcer were observed in 146 cases （100%）. Genital ulcer occurred in 115 cases （78.8%）, of which 76 were nan （76.8%）, 39 （82.9%） were uyghurs, the difference was not significant （P=0.391）. The initial presentation was oral ulcer in 83 cases （56.8%）, of which 60 cases （60.6%） were Han, 23 cases （48.9%） were the uyghurs. The second most common presentation was oral ulcer and genital ulcer, which occurred in 42 cases （28.8%）, of which 23 cases （23.2%） were Han, 19 cases （40.4%） were the uyghurs. More Han patients initially presented with both oral and genital ulcers than uyghur （P=0.032）. ② Skin lesions were recorded in 66 cases （45.2%）, of which 45 cases （45.4%） were Han, 21 cases （44.7%） were the uyghurs, the difference was not significant （P=0.930）. ③ Joint damage occurred in 40 cases （27.4%）, of which 22 cases （22.2%） were Han, 18 cases （38.3%） were the uyghurs. Joint damage wasmore frequently observed in Han than in uyghur （P=0.042）. ④Eye lesion happened in 21 cases （14.4%）, ofwhich 9 cases （9.1%） were Han, 12 cases （25.5%） were the uyghurs, ie, eye lesion of Uyghur was higher than Han （P=0.008）.⑤ Vascular lesions were detected in 8 cases （5.5%）, of which the 5 cases were Han, 3 cases were uyghurs, the difference was not significant （P=-0.712）. ⑥ Nervous lesions were observed in 2 cases （1.37%）, 1 was Han and one was uyghur, the difference was not significant （P=0.542）. Conclusion The most common clinical presentations of BD in Xinjiang region are oral and genitalulcers. Skin, joints, eye, vascular, nervous system can also be affected. Joint damage in Han is higher than Uyghur ,but eye lesion of Uyghur is more common than Han.