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脾切除术后感染患者超敏C-反应蛋白及降钙素原变化与预后的相关性研究 被引量:4

Correlation between changes of high-sensitivity C-reactive protein and procalcitonin and prognosis of splenectomy patients with postoperative infections
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摘要 目的探讨脾切除、贲门周围血管离断术术后感染患者超敏C-反应蛋白(h-CRP)与降钙素原(PCT)变化及与预后的相关性,为临床控制与降低术后感染提供参考依据。方法选取2014年12月-2015年68例脾切除、贲门周围血管离断术术后感染患者,将其设为试验组,选取同期脾切除、贲门周围血管离断术未感染的68例患者为对照组,采用电化学发光法检测两组患者的PCT水平,采用免疫比浊法测定h-CRP水平,比较两组患者的h-CRP与PCT水平变化及与预后的相关性。结果试验组术后感染患者PCT(16.38±4.47)ng/ml、h-CRP(45.30±19.70)mg/L、WBC(17.40±3.40)×109/L以及APCHEⅡ评分(24.56±7.79),显著高于对照组PCT(6.86±3.13)ng/ml、h-CRP(22.10±5.30)mg/L、WBC(11.30±2.60)×109/L、APCHEⅡ评分(13.12±6.21)差异有统计学意义(P<0.05);试验组术后感染患者入院后PCT、h-CRP与APCHEⅡ评分呈正相关(r=0.642和0.547);WBC与APCHEⅡ无相关性;试验组1、3、5dPCT、h-CRP水平,显著高于对照组(P<0.05),试验组第3天PCT、h-CRP水平达到峰值,并趋于下降趋势。结论脾切除、贲门周围血管离断术术后感染患者h-CRP和PCT与预后关系密切,应加强h-CRP和PCT水平监测,降低感染率。 OBJECTIVE To explore the correlation between the changes of high-sensitivity C-reactive protein(hCRP)and procalcitonin(PCT)and the prognosis of the splenectomy,pericardial devascularization patients with postoperative infection so as to provide guidance for clinical control of the postoperative infections.METHODS A total of 68 patients who received the splenectomy,pericardial devascularization from Dec 2014 to 2015and had postoperative infections were enrolled in the study and assigned as the experimental group,meanwhile,68 patients who received the splenectomy,pericardial devascularization but did not have infection were set as the control group.The PCT level of the two groups of patients was determined by using electrochemiluminescence immunoassay,and the h-CRP level was determined with the use of immunoturbidimetric assay.The levels of h-CRP and PCT were compared between the two groups of patients,and their correlation with the prognosis was observed.RESULTS The PCT level of the experimental group was(16.38±4.47)ng/ml,significantly higher than(6.86±3.13)ng/ml of the control group;the h-CRP level of the experimental group was(45.30±19.70)mg/L,significantly higher than(22.10±5.30)mg/L of the control group;the WBC counts of the experimental group were(17.40±3.40)×109/L,significantly more than(11.30±2.60)×109/L of the control group;the APCHEⅡscore of the experimental group was(24.56±7.79),significantly higher than(13.12±6.21)of the control group(P〈0.05).The PCT and h-CRP of the patients with postoperative infection in the experimental group were positively correlated with the APCHEⅡscore after the admission to the hospital(r=0.642 and 0.547);the WBC was not correlated with the APCHEⅡ.The levels of PCT and h-CRP of the experimental group were significantly higher than those of the control group on Day 1,3,and 5(P〈0.05);the levels of PCT and h-CRP of the experimental group reached the peak on Day 3and then showed downwards.CONCLUSIONThe h-CRP and PCT of the splenectomy,pericardial devascularization patients with postoperative infection are closely associated with the prognosis.It is necessary to strengthen the monitoring of the h-CRP and PCT levels so as to reduce the infection rate.
出处 《中华医院感染学杂志》 CAS CSCD 北大核心 2016年第18期4164-4166,共3页 Chinese Journal of Nosocomiology
基金 河南省卫生厅基金资助项目(2012764092X)
关键词 脾切除 术后感染 超敏C-反应蛋白 降钙素原 预后 Splenectomy Postoperative infection High-sensitivity C-reactive protein Procalcitonin Prognosis
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