急性白血病患儿呼吸道感染后微量元素及营养状态相关指标的变化研究

Study on changes of trace elements and nutritional state-related indexes of acute leukemia children complicated with respiratory tract infections

目的分析急性白血病合并呼吸道感染患儿微量元素及营养状态相关指标的变化,为白血病患儿呼吸道感染的控制提供参考依据。方法选取2014年1月-2015年11月治疗的42例急性白血病合并呼吸道感染患儿为A组,另选同期42例急性白血病呼吸道未感染患儿为B组,42名同龄健康儿童为C组;将3组儿童的血清微量元素、游离氨基酸及蛋白代谢指标进行比较,并比较A组上呼吸道感染和下呼吸道感染患者的检测结果。结果 A组的血清Fe、Zn及Se水平分别为(2.28±0.44)mmol/L、(8.37±1.15)μmol/L及(0.81±0.09)mmol/L,均低于B组的(3.34±0.53)mmol/L、(10.48±1.40)μmol/L、(1.02±0.11)mmol/L及C组的(4.59±0.64)mmol/L、(12.88±1.56)μmol/L、(1.20±0.15)mmol/L,A组的血清Cu水平为(19.84±1.81)μmol/L,均高于B组的(17.70±1.62)μmol/L及C组的(15.35±1.43)μmol/L,而A组的游离氨基酸及蛋白代谢指标均低于B组及C组,B组则低于C组,A组下呼吸道感染患者的检测结果低于上呼吸道感染,差异均有统计学意义(P<0.05)。结论急性白血病合并呼吸道感染患儿微量元素及营养状态相关指标呈现相对较差的状态,呼吸道感染的存在加重了上述指标的异常,应重视对该类患儿呼吸道感染的治疗及预防控制。

OBJECTIVE To investigate the changes of trace elements and nutritional state-related indexes of acute leukemia children complicated with respiratory tract infections so as to provide guidance for control of the respiratory tract infections in the acute leukemia children.METHODS A total of 42 acute leukemia children complicated with respiratory tract infections who were treated from Jan 2014 to Nov 2015 were chosen as the group A,meanwhile,42 acute leukemia children without respiratory tract infections were set as the group B,and 42 healthy children were assigned as the group C.The serum trace elements,free amino acids,and proteometabolism indexes were compared among the three groups of children,and the test results were observed and compared between the patients with upper respiratory tract infections and the patients with lower respiratory tract infections in the group A.RESULTS The level of serum Fe of the group A was（2.28±0.44）mmol/L,lower than（3.34±0.53）mmol/L of the group B and（4.59±0.64）mmol/L of the group C;the level of serum Zn of the group A was（8.37±1.15）μmol/L,lower than（10.48±1.40）μmol/L of the group B and（12.88±1.56）μmol/L of the group C;the level of serum Se of the group A was（0.81±0.09）mmol/L,lower than（1.02±0.11）mmol/L of the group B and（1.20±0.15）mmol/L of the group C.The level of serum Cu of the group A was（19.84±1.81）μmol/L,higher than（17.70±1.62）μmol/L of the group B and（15.35±1.43）μmol/L of the group C;however,the free amino acids and proteometabolism indexes of the group A were lower than those of the group B or C,while the free amino acids and proteometabolism indexes of the group B were lower than those of the group C.Among the patients in the group A,the test results of the patients with lower respiratory tract infections were lower than those of the patients with upper respiratory tract infections,and there was significant difference（P〈0.05）.CONCLUSION The acute leukemia children complicated with respiratory tract infections present with poor state of trace elements and nutritional state-related indexes,and the respiratory tract infections may exacerbate the above abnormal indexes.It is necessary to pay attention to the prevention,control,and treatment of the respiratory tract infections in such group of children.