匹多莫德对细菌感染性肺炎患儿炎性因子的影响研究

Impact of pidotimod on inflammatory factors of children with bacterial pneumonia

目的探讨匹多莫德辅助治疗细菌感染性肺炎患儿对血清降钙素原(PCT)、C-反应蛋白(CRP)、前白蛋白(PA)及白细胞计数(WBC)的影响,为细菌感染性肺炎治疗提供参考依据。方法选取2015年2-10月收治的80例细菌感染性肺炎患儿,随机分为观察组与对照组,每组40例,两组患儿均给予抗感染、止咳、化痰、平喘、吸氧等治疗,观察组加用匹多莫德辅助治疗,观察两组患儿治疗前、治疗1周后血清PCT、CRP、PA及WBC变化。结果两组治疗前血清PCT、CRP、PA及WBC比较,差异无统计学意义,治疗后与治疗前比较PCT、CRP、WBC下降,PA升高,观察组治疗后上述指标较对照组改善更为明显,以上指标组间及组内比较差异均有统计学意义(P<0.05);发热消退时间、咳嗽消失时间、肺部啰音消失时间、住院时间,PCT、CRP、PA及WBC恢复正常时间,观察组均短于对照组(P<0.05);观察组治疗总有效率为95.00%,高于对照组的77.50%(P<0.05)。结论匹多莫德辅治儿童细菌感染性肺炎,有利于改善血清PCT、CRP、PA及WBC水平及临床症状,缩短病程,提高治疗效果。

OBJECTIVE To explore the impact of pidotimod on serum procalcitonin（PCT）,C-reactive protein（CRP）,prealbumin（PA）,and white blood cell（WBC）counts of children with bacterial pneumonia so as to provide guidance for treatment of the bacterial pneumonia.METHODS A total of 80 children with bacterial pneumonia who were treated in the hospital from Feb 2015 to Oct 2015 were enrolled in the study and randomly divided into the observation group and the control group and the observation group,with 40 cases in each group.The two groups of children were given the therapies such as anti-infection,anti-tussive,dissipating phlegm,relieving asthma,and oxygen uptake;the observation group was treated with additional pidotimod.The changes of serum PCT,CRP,PA,and WBC were observed and compared between the two groups of patients before the treatment and after the treatment for 1week.RESULTS There was no significant difference in the serum PCT,CRP,PA,or WBC between the two groups before the treatment;the levels of PCT,CRP,and WBC declined after the treatment,however,the level of PA was elevated,the above indexes of the observation group were improved more significantly than those of the control group after the treatment（P〈0.05）.The subsided time of fever,time of disappearance of cough,time of disappearance of lung rales,and length of hospital stay,as well as time of recovery of PCT,CRP,PA,and WBC were shorter in the observation group than in the control group（P〈0.05）.The total effective rate of treatment of the observation group was 95.00%,higher than 77.50% of the control group（P〈0.05）.CONCLUSIONThe use of pidotimod for authilliary treatment of the children with bacterial pneumonia may facilitate the improvement of levels of serum PCT,CRP,PA,and WBC as well as the clinical symptoms,shorten the disease course,and improve the therapeutic effect.