中药及其活性成分与氯吡格雷抗血小板聚集的相互作用

Interaction and active components of traditional Chinese medicine with clopidogrel on platelet aggregation

氯吡格雷是临床常用的抗血小板聚集药物,临床上常与中药制剂联合使用。加强中药及其活性成分与氯吡格雷相互作用机制的研究,对提高抗血小板聚集作用,协同改善氯吡格雷抵抗提供依据。笔者综述了国内外相关文献中药及其活性成分与氯吡格雷相互作用的研究进展。细胞色素P450代谢酶、肝羧酸酯酶、P糖蛋白是中药及其活性成分与氯吡格雷发生相互作用的主要环节,也有些中药及其活性成分在药效学方面与氯吡格雷有协同抗血小板聚集作用。

Clopidogrel is commonly used as an anti-platelet aggregation drug in the clinical treatment ,which is often used in combination with traditional Chinese medicine .Strengthening the study on the interaction mechanism of Chinese herbal medicine and its active components with clopidogrel ,to improve the effect of anti-platelet aggregation and the therapeutic effect of clopidogrel resistance .The research progress on the interaction of Chinese herbal medicine and its active components with clopidogrel were summarized in domestic and foreign literatures .Cytochrome P450 ,liver carboxylesterase ,P glycoprotein is a major part of the interaction of traditional Chinese medicine and its active ingredient of clopidogrel .Some active components in Chinese medicine have synergistic effect of clopidogrel on platelet aggregation .