海带多糖抗肿瘤活性研究进展

Progress on the anti-tumor activity of seaweed polysaccharides

海带多糖不仅对肿瘤细胞具有直接抑制作用,还可以通过增强机体的免疫功能、抑制肿瘤转移而对肿瘤细胞产生间接抑制作用。海带多糖可减轻肿瘤化疗药物耐药性,抑制自由基产生、加快自由基清除,显示抗突变、抗辐射作用,这可能也会在一定程度上抑制肿瘤细胞的生长及预防肿瘤的发生。此外,海带多糖对抗肿瘤化疗药物有增效作用,减轻抗肿瘤化疗药物的毒副作用;对放疗所致机体免疫细胞的损伤也显示一定对抗作用,可以作为临床抗肿瘤辅助治疗药物。笔者对近10年来海带多糖抗肿瘤活性及其作用机制研究进行了简要综述,涵盖了从2004年到2015年的28篇文献,期望对海带多糖的进一步研究及深度开发提供一定参考。

Seaweed polysaccharides are not only a direct inhibitory effect on tumor cells ,but also an indirect therapeutic effected by enhancing immune function or inhibiting tumor cell metastasis .Seaweed polysaccharides could inhibit the growth of tumor cells due to reducing tumor chemotherapy drug resistance and inhibiting free radical generation ,accelerating free radical scavenging .Moreover ,seaweed polysaccharides have a synergistic effect with chemotherapy drugs to reduce their side effects and protest patients from radiotherapy-induced immune cell damage .Therefore ,seaweed polysaccharide could be used as adju-vant therapeutic agents .the antitumor activity and mechanism of seaweed polysaccharides were summarized ,covering 28 arti-cles published in the years from 2004 to 2015 .