胰岛素样生长因子mRNA结合蛋白3在胰腺癌中的表达及意义

Expression of insulin-like growth factor mR NA binding protein 3 in pancreatic cancer and its significance

目的:探讨胰岛素样生长因子m RNA结合蛋白3(IMP3)在胰腺癌组织中的表达及其临床意义。方法:用免疫组化法检测126例胰腺癌组织以及12例正常胰腺组织中的IMP3表达,分析IMP3表达与胰腺癌患者临床病理因素及预后的关系。结果:胰腺癌组织中IMP3的阳性表达率明显高于正常胰腺组织(93.65%vs.0.00%,P<0.000)。IMP3的表达水平与胰腺癌患者的肿瘤大小、淋巴结转移、肿瘤侵袭深度、TNM分级有关(均P<0.05);IMP3高表达患者的中位生存时间明显低于IMP3低表达患者(9.5个月vs.17.8个月,P=0.000)。结论:IMP3在胰腺癌组织中表达率增高,且其表达水平与胰腺肿瘤的发生、发展密切相关,IMP3高表达患者预后不良。

Objective： To investigate the expression of insulin-like growth factor mRNA binding protein 3 （IMP3） in pancreatic cancer tissue and its clinical signiifcance. Methods： The IMP3 expressions in 126 specimens of pancreatic cancer tissue and 12 specimens of normal pancreatic tissue were determined by immunohistochemical staining. The relations of IMP3 expression with clinicopathologic factors and prognosis of pancreatic cancer patients were analyzed. Results： hTe IMP3 positive expression rate in pancreatic cancer tissue was signiifcantly higher than that in normal pancreatic tissue （93.65%vs. 0.00%,P＆lt;0.000）. hTe IMP3 expression was signiifcantly associated with the tumor size, lymph-node metastasis, depth of invasion and TNM stage of the pancreatic cancer patients （allP〈0.05）; the median survival time in patients with high IMP3 expression was signiifcantly shorter than that in patients with low IMP3 expression （9.5 monthsvs. 17.8 months,P=0.000）. Conclusion： IMP3 expression rate is increased in pancreatic cancer tissue, and its expression level may be closely related to the occurrence and development of pancreatic cancer. Further, those patients with high IMP3 expression may face a poor prognosis.