联合疗法对老年帕金森病便秘病人生活质量及心理状态的影响

Effects of the Psychological State and Life Quality of Constipation in elderly Patients with Parkinson's Disease Treated with Combined Therapy

目的探讨联合疗法对老年帕金森病(PD)便秘病人生活质量及心理状态的影响。方法纳入明确诊断为老年PD便秘病人45例,随机分为对照组(22例)和观察组(23例)。对照组予聚乙二醇4000散,20 g,冲服,1次/日;观察组采用联合疗法,聚乙二醇4000散,20 g,冲服,1次/日,联合聚卡波非钙片,1.0 g,口服,3次/日。两组病人均连续治疗2周,观察比较临床症状、生活质量及心理状态变化情况。结果成功完成治疗方案及随访者共39例,观察组20例,对照组19例,连续治疗2周后两组病人排便相关临床症状均有改善(P<0.05),但观察组显著高于对照组(90.00%vs 68.42%,P<0.05);两组老年PD便秘病人治疗后生活质量及心理状态评分均有改善(P<0.05),观察组病人的改善情况显著优于对照组(P<0.05)。结论联合疗法能够缓解老年PD便秘病人临床症状,有效改善生活质量和心理状态。

Objective To observe and evaluate clinical effects of the psychological state and life quality of constipation in elderly patients with Parkinson＇s disease（PD） treated with combined therapy.Methods Forty -five elderly patients with PD were randomly di vided into control group （ n = 22, Macrogol 4000 powder, 20 g, oral, QD） and treatment group （ n = 23, Macrogol 4 000 powder, 20 g, oral, QD ＋ Calcium Polycarbophil, 1.0 g, oraI,TID）.They were treated for 2 weeks.The psychological state and life quality of constipation were evaluated and compared.Results After 2 weeks treatment,39 elderly patients completed this research （19 patients in control group and 20 patients in treatment group）.There were statistical differences in terms of the total effective rate（90.00% vs 68. 42% ）, psychological state and life quality of the treatment group was better（ P 〈0.05）.Conclusion Combined therapy is safe and effective for constipation in elderly patients with PD,and can improve the psychological state and life quality.