血管生成拟态与大肠癌肝转移相关性探究

Study of relationship between vasculogenic mimicry and liver metastasis in patients with colorectal cancer

目的探讨血管生成拟态(vasculogenic mimicry,VM)与大肠癌肝转移相关性。方法应用免疫组织化学方法检测115例大肠癌(其中伴肝转移25例,无肝转移90例)组织中的VM;并随访观察这些患者术后2年有无癌复发和肝转移。结果伴肝转移大肠癌患者癌组织中有64.0%VM阳性,无肝转移组仅26.7%VM阳性。无肝转移组患者术后2年内癌复发(P=0.0003)和肝转移(P<0.0003)发生与VM生成相关。结论 VM与大肠癌复发和肝转移呈正相关。

Objective To observe the relationship between vasculogenic mimicry （VM） and liver metastasis in patients with colorectal cancer. Methods VM in 115 patients with colorectal cancer was examined by immunohistochemical staining. Of them, 25 cases were with liver metastases and 90 without liver metastases. Cancer recurrence and liver metastases of these patients 2 years after operation were followed up. Results VM positivity was examined in 64.0% of patients with liver metastases, while only 26.7% of patients without liver metastases showed VM positivity. Recurrence and liver metastases of patients without liver metastases before operation were significantly related to VM existence, with P values of 0.000 3 and less than 0.000 3, respectively. Conclusion VM is positively associated with recurrence and liver metastasis of colorectal cancer.