摘要
以芳香醛、海因为原料,水为溶剂,经Knoevenagel缩合反应制得5-芳亚甲基海因后,再在室温超声波辐射下与靛红和L-脯氨酸发生1,3-二极环加成一锅反应,得到一系列双螺环化合物,收率为78%～94%.对产物结构进行红外、核磁及质谱表征.
Series of dispirooxindole derivatives were synthesized in one-step from aromatic alde- hydes and hydantoin by Knoevenagel condensation to afford 5-arylideneimidazolidine-2, 4-diones, which were subjected to 1, 3-dipoiar cyclo-addition with isatin and L-proline under ultrasonic irra- diation with yields of 78%--94%. The structure of the products were confirmed by infrared, nu- clear magnetic resonance and mass spectrometry.
出处
《淮海工学院学报（自然科学版）》
CAS
2016年第3期55-57,共3页
Journal of Huaihai Institute of Technology:Natural Sciences Edition
基金
江苏省科技厅前瞻性联合研究项目(BY2015049-02)
连云港市产学研联合研究项目(CXY1520)
淮海工学院江苏省海洋生物技术重点实验室开放课题(2014HS005)
淮海工学院江苏省海洋药物活性分子筛选重点实验室开放课题(2015HYB02)
关键词
双螺环化合物
超声波辐射
1
3-二极环加成
合成
dispirooxindole derivative
ultrasonic irradiation
1, 3-dipoiar cycloaddition
synthesis
