miRNA与结肠癌化疗敏感性关系的研究进展

Advances on the researches of miRNA and chemotherapy sensitivity of colon cancer

结肠癌是目前世界范围内发病率排第四的肿瘤,我国结肠癌发病率和死亡率都处于上升趋势。对于结肠癌的治疗目前主要是外科手术加药物化疗,但化疗效果并不让人满意。研究发现miRNA与结肠癌化疗敏感性存在密切关系。增强关于miRNA与结肠癌药物敏感性的相关认识将帮助新型药物的开发、临床用药方案的合理制定。本文就miRNA对结肠癌化疗敏感性的影响作一概述。

Nowadays colon cancer has become the fourth most common malignant tumor worldwide. However, the in- cidence rate and the mortality rate of colon cancer keep rising in China. To deal with it, we usually appeal to surgical operations and chemotherapies, which are accompanied with unsatisfactory outcomes. Some researches have shown us that microRNA （Mir） is closely related to the chemotherapy sensitivity of colon cancer. The knowledge of the relationship between mirs and the chemotherapy sensitivity will obviously help us with the clinical therapy and the development of new drugs. In this paper, we review the progress on the correlation with miRNAs and chemotherapy sensitivity of colon cancer.