依那普利叶酸片对H型高血压病人颈动脉粥样硬化斑块的影响

Effect of Enalapril and Folate Tablet on Carotid Atherosclerotic Plaque in Patients with Htype Hypertension

目的探讨依那普利叶酸片对合并高同型半胱氨酸血症高血压病人颈动脉粥样硬化斑块的影响。方法收集266例H型高血压病人,分为治疗组(依那普利叶酸片组)和对照组(依那普利组),分别于治疗前、治疗后2个月、治疗后10个月评估血压、血清同型半胱氨酸、颈动脉内-中膜厚度、粥样硬化斑块面积及数量情况。结果与治疗前及对照组比较,治疗组在10个月后血清同型半胱氨酸降低至(13.1±6.9)μmol/L,差异有统计学意义(P<0.05),治疗10个月颈动脉内-中膜变薄及斑块面积、数量均明显减少,差异有统计学意义(P<0.05)。结论依那普利叶酸片可降低H型高血压病人血清同型半胱氨酸水平,较长时间服用可稳定H型高血压病人颈动脉粥样斑块。

Objective To investigate the effect of enalapril and folate tablet on carotid atherosclerotic plaque（AP）in patients with H type hypertension.Methods Two hundreds and sixty six patients with H type hypertension and carotid AP were randomly divided into two groups：investigation group and control group.Investigation group received enalapril and folate tablet and aspirin enteric coated,while the control group received enalapril and aspirin enteric coated.The blood pressure,serum homocysteine（Hcy）level and the intima midia thickness（IMT）of carotid artery,the area of carotid AP,and the number of AP were measured before treatment, after 2 months and 10 months of treatment, respectively. Results Compared with the before treatment and control group,after 10 months of treatment,the blood pressure,Hcy,IMT of carotid artery,the area of carotid AP and the number of AP significantly reduced in the investigation group（P〈0.05）.But blood pressure,Hcy after 2 months of treatment were reduced compared with before treat-ment（P〈0.05）.Conclusion Enalapril and folate tablet can reduce serum Hcy andeffectively stabilis carotid AP in patients with H type hypertension.