脑梗死患者血同型半胱氨酸变化及影响因素分析

The changes of plasma homocysteine in cerebral infarction patients

目的探讨脑梗死患者血同型半胱氨酸变化及相关影响因素。方法对2014-06—2015-05在该院进行治疗的脑梗死患者160例及健康体检者120名，采用循环酶法对血清同型半胱氨酸水平进行检测，并分析其相关影响因素。结果脑梗死患者的血同型半胱氨酸水平[（21．92±12．13）μmol/L]高于正常人[（10．46±2．36）μmol／L]。血同型半胱氨酸的影响因素主要有丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）、谷氨酰基转移酶（GGT）、年龄、性别等。结论高血同型半胱氨酸是引发脑梗死的危险性因素，ALT、AST、GGT的含量与血同型半胱氨酸的浓度呈正相关。

Objective To explore the changes of plasma homocysteine（Hcy） and the correlative factors in cerebral infarction patients. Methods One hundred and sixty cerebral infarction patients and 120 healthy subjects were selected in our hospital from June 2014 to May 2015. Cycling enzymatic method was used to measure the serum homocysteine level. The kidney and liver functions were tested. The results were compared and analyzed. Results The serum homocysteine level in the cerebral infarction patients （21.92±12. 13 ） μmol/L was higher than that in the healthy subjects （ 10. 46 ± 2. 36） μmol/L. The blood glucose, live and kidney functions in the cerebral infarction pa- tients were different from those in the healthy subjects. ALT, AST, GGT, age and Render were the main influencing factors of Hcy. Conclusion The risk factors of cerebral infarction are caused by high level of Hcy. The contents of ALT, AST and GGT are positively correlated to Hcy concentration.