静脉滴注阿莫西林克拉维酸钾致直肠黏膜脱垂

Rectal mucosa prolapse caused by an intravenous infusion of amoxicillin and clavulanate potassium

1例63岁女性患者因支气管肺炎给予阿莫西林克拉维酸钾1．2g静脉滴注、2次／d。用药第1天2次滴注该药约20min患者均出现恶心和肛门坠胀感，未予处理，均在滴注完毕约3h后缓解。第2天首次静脉滴注该药，约20min后患者再次出现上述症状，并出现直肠黏膜脱垂，立即停用阿莫西林克拉维酸钾。第3天起给予头孢曲松钠2g静脉滴注、1次／d。患者咳嗽、咳痰在换药第3天好转，第8天消失，未再出现直肠黏膜脱垂。

A 63-year-old female patient with bronchopneumonia received an Ⅳ infusion of amoxicillin clavulanic acid potassium 1.2 g twice daily. The patient developed nausea and rectal tenesmus about 20 minutes after the start of amoxicillin clavulanic acid potassium treatment each time on the first day. No treatments were given and the symptoms relieved gradually 3 hours after finishing the Ⅳ infusion. The patient developed the above-mentioned symptoms again about 20 minutes after the start of amoxicillin clavulanic acid potassium treatment on the second day, and rectal mucosal prolapse appeared at the same time. The amoxicillin clavulanic acid potassium was stopped immediately and an Ⅳ infusion of ceftriaxone sodium 2 g once daily was given on the third day. After 3 days of ceftriaxone sodium treatment, the patient＇s cough and expectoration were improved and disappeared on the 8th day, and the rectal mucosal prolapse did not recur.