女性闭经患者血清FSH、LH、PRL水平测定分析

Significance of serum FSH,LH,PRL level detection for the female menopause patients

目的:通过检测闭经女性患者血清中卵泡刺激素(FSH)、黄体生成素(LH)、催乳素(PRL)的水平,探讨其在闭经女性患者中的意义。方法:选取本院妇科门诊就诊的52例闭经患者为观察组,选取本院健康体检中心月经正常的52例女性为对照组。选取对象的时间均来自2012年4月至2015年4月在本院进行性激素检查的女性。采用化学发光免疫法分别检查两组女性血清中FSH、LH、PRL、雌二醇(E_2)、孕酮(P)的水平,以进行对照研究。结果:观察组患者血清中FSH、LH、PRL的值分别为(14.68±13.26)m U/mL、(12.321±10.14)m U/mL、(38.85±33.14)ng/mL明显高于对照组血清中的水平,具有明显的统计学(P<0.01),观察组E_2的水平为(40.98±15.48)pg/mL明显低于对照组(51.54±8.87)pg/mL(P<0.05),对照组和观察组孕酮(P)的值分别为(8.55±0.30)ng/mL和(0.56±0.26)ng/mL有明显差异,具有统计学意义(P<0.05)。闭经时间>6个月患者血清中PRL(18.67±6.87)mu/mL、FSH(19.23±5.14)mu/mL、LH(45.85±3.124)ng/mL的水平明显高于闭经时间<6个月激素水平(P<0.049)。但闭经时间>6个月患者血清中P(8.37±12.26)ng/mL、E_2(0.42±0.53)ng/mL水平则低于闭经时间<6个月的患者血清内其激素的水平(P<0.044)。结论:通过对闭经女性患者性激素水平的检测,可以根据血清中性激素水平的高低进行病因诊断和基本的对症治疗。

Objectives： To explore the clinical significance of serum FSH, LH, PRL level detection for amenorrhea women. Methods： 52 amenorrhea patients in our hospital from April 2012 to April 2015were selected as observation group. In the same period, 52 women with normal menstrual were selected as control group. Radioimmunoassay was used to detect the serum levels of FSH, LH, PRL, E2 , P of the two groups. Results ： In observation group, the serum levels of FSH, LH and PRL were respectively 14.68 ± 13.26 mu/ml, 12. 321 ± 10. 14 mu / ml and 38. 85 ± 33. 14 ng/ml, which were significantly higher than these in control group （P 〈 0. 01 ）. E2 level （40. 98 ± 15.48 pg/ml） in observation group was significantly lower than that in control group （51.54 ±8.87pg / ml） （p =0. 0420）. Progesterone （P） levels of control group and observation group were 8.55 ±0. 30 pg/ml and 0. 56 ±0.26 pg/ml, with statistically significant difference （p = 0. 4346）. The serum levels of PRL （ 18.67 ±6. 87 mu/ml）, FSH （19, 23±5.14 mu/ml）, LH （45. 85 ± 3. 85 ng/ml） of patients with〉 6 months ofamenorrhea were significantly higher than those of patients with 〈 6 months hormone （P 〈 0. 049）. Bu serum levels of P （8.37 ±12.26 ng/ml）, E2 （0. 42 ± 0. 53 ng/ml） of patients with 〉 6 months amenorrhea were significantly lower than these of patients 〈 6 months of amenorrhea （P 〈 0. 044）. Conclusion： Through the detection of sex hormone level of menopause women, suitable etiology diagnosis and symptomatic treatment can be selected.