2型糖尿病高尿酸血症与代谢综合征相关性的研究

To study the relationship in type 2 diabetes with hyperuricemia and metabolic syndrome

目的对672例2型糖尿病患者进行多因素调查,探讨糖尿病患者高尿酸血症与代谢综合征及其组分的相关性,以利于对心血管病的防治。方法选安贞及崔各庄社区已确诊的糖尿病672例患者,测量身高、体质量、颈围、腰围、血压,并测定血糖、糖化血红蛋白、血尿酸、血脂谱,以高尿酸及正常尿酸分2组,用SPSS17.0进行统计分析。结果本研究人群高尿酸血症总患病率为8.04%,明显低于沿海山东人群。高尿酸血症组体质量指数、颈围、腰围、腰臀比、舒张压、空腹血糖、餐后2h血糖、糖化血红蛋白、丙氨酸氨基转移酶、尿素氮、血尿酸均明显高于正常尿酸组。代谢综合征及肥胖或超重的患病率在高尿酸血症组为75.93%、77.78%,正常尿酸组是58.9%、56.8%,P=0.014、0.003。高尿酸血症组具有3个及4个代谢综合征组分数目的患者多于正常尿酸组,75.93%vs.58.90%(P<0.01);多因素Logistic回归分析显示,影响高尿酸血症的因素有体质量指数、糖化血红蛋白、丙氨酸转氨酶、尿素氮。结论北京糖尿病患者高尿酸血症患病率低于沿海人群,但其合并代谢综合征及心血管危险因素很多且重,值得社区医生重视综合干预。

Objective To investigate the multi factor for type 2diabetes with hyperuricemia and metabolic syndrome for prevention cardiovascular disease.Methods 672 cases diagnosed type 2diabetes were selected in Beijing Anzhen and Cuigezhuang communities to measure height,weight,neck circumference,waist,BMI,blood pressure,fasting plasma glucose,HbA1 cand lipid profile.Results The prevalence of HUA in 672 cases is 8.04%.It was significantly lower than coastal area population in Shandong Province.BMI,neck circumference,waist,DBP,FBG,2hPG,HbA1 c,GLT,BUN,blood uric were significantly higher than NUA group.The prevalence of MS and fatty in HUA group is 75.93%,77.78%.While in NUA group is 58.9%,56.8% respectively P=0.014,0.003.Logistic regression analysis showed that BMI,HbA1 c,ALT,BUN were associated with hyperuricemia in T2 DM.Conclusion The prevalence of HUA in Beijing diabetic patients was lower than coastal area population,but complicated MS and cardiovascular risk factor were high and seriously.