2型糖尿病肾病患者尿脂联素与尿白蛋白的相关性分析

Relationship between urinary adiponectin and urinary albumin in patients with type 2 diabetic ne-phropathy

目的：探讨2型糖尿病肾病患者尿脂联素与尿白蛋白的相关性。方法选择2012年1月至2013年8月收治的2型糖尿病患者90例，根据尿微量白蛋白/肌酐（ACR）水平将患者分为三组，每组30例。正常对照组（A 组）：ACR 〈30 mg/ g；微量白蛋白尿组（B 组）：ACR 30-300 mg/ g；大量白蛋白尿组（C 组）：ACR 〉300 mg/ g。采集血尿标本，尿脂联素应用酶联免疫吸附法（ELISA）。结果尿脂联素：C 组[（9.21±6.32）μg/ ml]高于 B 组[（5.72±3.21）μg/ ml]和 A 组[（0.38±0.31）μg/ ml]，P 均〈0.01；且 B 组高于 A 组（P 〈0.01）。糖化血红蛋白（HbA1c）：C 组[（8.82±2.14）%）]及 B 组[（8.70±2.64）%）]高于 A 组[（7.55±1.83）%）]，差异有统计学意义（P 〈0.05）。尿脂联素与 ACR、HbA1c 呈正相关（r =0.73、0.12，P 均〈0.05）。结论2型糖尿病肾病患者尿脂联素与 ACR、HbA1c 呈正相关。

Objective To investigate the relationship between urinary adiponectin and urinary albumin in patients with type 2 diabetic nephropathy. Methods Form January 2012 to August 2013,90 patients with type 2 diabetes were selected,they were divided into three groups based on tertiles of urina-ry albumin / creatinine（ACR）,with 30 cases in each group. Control group：ACR 〈 30 mg / g;Microalbu-minuria group：ACR 30 - 300 mg / g;macroalbuminuria group：ACR 〉 300 mg / g. Blood and urine sam-ples were collected,urinary adiponectin concentrations were measured by enzyme linked immuno-sorbent assay（ELISA）. Results Urinary adiponectin level was higher in macroalbuminuria group[（9. 21 ± 6. 32）μg / g]than that in microalbuminuria group[（5. 72 ± 3. 21）μg / g]and control group[（0. 38 ± 0. 31）μg / g],P 〈 0. 01,and the urinary adiponectin level was higher in microalbuminuria group than that in control group,the difference was statistically significant（P 〈 0. 01）. HbA1c level was higher in macroalbuminuria group[（8. 82 ± 2. 14）% ]and microalbuminuria group[（8. 70 ± 2. 64）% ]than that in control group[（7. 55 ±1. 83）% ],P 〈0. 05. There was a positive correlation between urinary adiponec-tin level and HbA1c,ACR（r = 0. 73,0. 12 respectively,P 〈 0. 05）. Conclusions There is a positive correlation between urinary adiponectin level and HbA1c,ACR in patients with type 2 diabetes.