加巴喷丁对癫痫大鼠海马神经元及P75NTR表达的影响被引量：3

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摘要加巴喷丁（gabapentin,GBP）是近几年应用于临床的新型抗癫痫药,国外一些研究已证实了加巴喷丁具有神经保护作用。本研究通过腹腔注射戊四氮建立癫痫持续状态大鼠模型,观察大鼠行为学改变,海马神经元组织学改变和凋亡相关基因P75NTR的表达变化,探讨加巴喷丁的抗癫痫作用及可能的神经保护机制。

作者臧颖卓王维平刘瑞春何斌史立信王清涛

机构地区河北省清河县人民医院神经内科河北医科大学第二医院神经内科河北省清河县人民医院神经外科河北省清河县人民医院影像科

出处《山西医药杂志》 CAS 2016年第17期2000-2002,共3页 Shanxi Medical Journal

基金河北省科技支撑计划(20100551)

关键词加巴喷丁 P75NTR 海马神经元癫痫大鼠大鼠行为学癫痫持续状态神经保护机制神经保护作用凋亡相关基因抗癫痫药

分类号 R742.1 [医药卫生—神经病学与精神病学]

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参考文献14

1Racine RJ.Modification of seizure activity by electrical stimulation:Ⅱ.Motor seizure[J].Electroencephalogr Clin Neurophysiol,1972,32(3):281-294.
2Tchekalarova J,Ivanova N,Pechlivanova D,et al.Strain-dependent effects of subchronically infused losartan against kainic acid-induced seizures,oxidative stress,and heat shock protein 72expression[J].Cell Mol Neurobiol,2014,34(1):133-142.
3Mefford HC.Thinking about cognition and epilepsy[J].Epilepsy Behav,2014,41(12):276.
4赵冉冉,徐晓臣,檀国军,王维平,张文忠,刘吉祥.α-硫辛酸对戊四氮点燃大鼠认知功能的保护作用及机制探讨[J].河北医科大学学报,2015,36(3):257-260. 被引量：5
5Meng FY,Zhang LC,Liu Y,et al.Efficacy and safety of gabapentin for treatment of postherpetic neuralgia:a meta-analysis of randomized controlled trials[J].Minerva Anestesiol,2014,80(5):556-567.
6Yoshizumi M,Parker RA,Eisenach JC,et al.Gabapentin inhibitsγ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats[J].Anesthesiology,2012,116(6):1347-1353.
7Tu W,Xu X,Peng L,et al.DAPK1interaction with NMDA receptor NR2Bsubunits mediates brain damage in stroke[J].Cell,2010,140(2):222-234.
8易传安,何绘敏,胡祥上,岳晓玲,王滨.NMDA受体NR1、NR2A/B在丘脑前核-海马CA1、CA3脑区和齿状回的分布与表达[J].中国老年学杂志,2011,31(7):1152-1155. 被引量：7
9Kukkar A,Bali A,Singh N,et al.Implications and mechanism of action of gabapentin in neuropathic pain[J].Arch Pharm Res,2013,36(3):237-251.
10Yudowski GA,Olsen O,Adesnik H,et al.Acute inactivation of PSD-95destabilizes AMPA receptors at hippocampal synapses[J].PLoS One,2013,8(1):e53965.

二级参考文献47

1Huang E J, Reichardt LF. Neurotrophins: roles in neuronal development and function[ J ]. Annu Rev Neurosci, 2001,24:677 -736.
2Bibel M, Barde YA. Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system[ J]. Genes Dev, 2000, 14:2919 - 2937.
3Turner B J, Cheah IK, Maefarlane K J, et al. Antisense peptide nucleic acid-mediated knockdown of the p75 neurotrophin receptor delays motor neuron disease in mutant SOD1 transgenic mice[J].J Neurochem, 2003, 87:752-763.
4Hashimoto Y, Kaneko Y, Tsukamoto E, et al. Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid- beta peptides via p75NTR/PLAIDD[J]. J Neurochem, 2004, 90 : 549 - 558.
5Peng S, Wuu J, Mufson E J, et al. Increased proNGF levels in subjects with mild cognitive impairment and mild Alzheimer disease [J]. J Neuropathol Exp Neurol, 2004, 63:641 -649.
6Beattie MS, Harrington AW, Lee R, et al. ProNGF induces p75- mediated death of oligodendrocytes following spinal cord injury[ J]. Neuron, 2002, 36 (3) : 375 -386.
7Higuchi H, Yamashita T, Yoshikawa H, et al. PKA phosphorylates the p75 receptor and regulates its localization to lipid rafts[J]. EM- BO J, 2003, 22:1790-1800.
8Pedraza CE, Podlesniy P, Vidal N, et al. Pro-NGF isolated from the human brain affected by Alzheimer's disease induces neuronal apoptosis mediated by p75NTR[ J]. Am J Pathol, 2005,166:533 - 543.
9Hempstead BL. Dissecting the diverse actions of pro- and mature neurotrophins[ J]. Curr Alzheimer Res, 2006, 3 : 19 - 24.
10Fahnestock M,Yu G, Coughlin MD. ProNGF: a neurotrophic or an apoptotic molecule? [J]. Prog Brain Res, 2004, 146:101 -110.