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伊力替康联合顺铂与依托泊苷联合铂类一线治疗广泛期小细胞肺癌疗效观察 被引量:2

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摘要 小细胞肺癌(SCLC)约占肺癌总数的16%[1],特点是分化程度低、恶性程度高,容易发生复发、转移及耐药。依托泊苷联合顺铂或卡铂是治疗广泛期SCLC的标准方案,其诱导缓解率高,中位生存期为9.4~12.8个月,2年总存活率为5.2%~19.5%[2,3]。伊力替康是拓扑异构酶Ⅰ抑制剂,可以抑制DNA单链断裂后修复,干扰DNA复制和转录,从而导致肿瘤细胞死亡。
出处 《山西医药杂志》 CAS 2016年第18期2159-2161,共3页 Shanxi Medical Journal
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