新疆哈萨克族食管癌的发生与人类乳头状瘤病毒感染相关性的临床研究

The Correlation of HPV Infection and Esophageal Carcinoma of Kazak in Xinjiang Autonomous Region

目的探讨新疆哈萨克族食管癌的发生与人类乳头状瘤病毒感染相关性。方法选取新疆哈萨克族食管癌患者的石蜡组织标本40例作为研究组,并选取同期的40例正常食管黏膜为对照组,对切片进行组织学观察分型,分析食管癌与人类乳头状瘤病毒感染相关性。结果研究组HPV-16的阳性检出率为57.5%,对照组HPV-16的阳性检出率为30.0%,两组比较,差异有统计学意义(P<0.05)。Ⅰ+Ⅱ期HPV-16检出阳性率54.55%,Ⅲa期HPV-16检出阳性率58.82%,Ⅲb期HPV-16检出阳性率66.67%,TNM分期与食管鳞状细胞癌组织中HPV-16的阳性率间对比,差异无统计学意义(P>0.05)。结论新疆哈萨克族食管癌发病过程与HPV-16感染具有一定关系,但HPV-16感染与食管癌的组织分化程度无明显的相关性。

Objective To investigate the correlation of HPV infection and esophageal carcinoma of Kazak in Xinjiang autonomous region.Methods The parafifn embedded tissue samples from 40 cases of Kazak patients with sophageal carcinoma were selected as the observation group, and 40 cases of normal esophageal mucosas tissue samples were selected as the control group, then observed the histopathologic typing of all samples, evaluated the correlation of HPV infection and esophageal carcinoma.ResultsThe positive detection rate of HPV-16 in the observation group （57.5%） was signiifcantly higher than that of the control group （30.0%） （P〈0.05）; There is no signiifcant difference of the positive detection rates of HPV-16 inⅠ andⅡesophageal carcinoma （54.55%）,Ⅲ a esophageal carcinoma andⅢ b esophageal carcinoma （66.67%） （P〉0.05）.ConclusionThe process of esophageal cancer of Kazak was associated with HPV-16 infection, but the differentiation of esophageal carcinoma tissue has no apparent correlations to HPV-16 infection.