新辅助治疗直肠癌的临床应用及疗效观察

Observation on Clinical Application and Curative Effect of Neoadjuvant Therapy for Rectal Cancer

目的探讨新辅助治疗直肠癌的应用及效果。方法将70例患者分为两组。对照组(35例)均给予新辅助单纯放疗,观察组(35例)则给予新辅助治疗联合同期放化疗,评估两组患者治疗效果的差异。结果观察组治疗有效率(85.7%)高于对照组(54.3%),差异具有统计学意义(P<0.05)。观察组术中肛门保留率45.71%(16/35)、并发症发生率25.71%(9/35)、随访期间复发率5.71%(2/35);对照组术中肛门保留率25.71%(9/35)、并发症发生率22.86%(8/35)、随访期间复发率8.57%(3/35)。两组患者术中肛门保留率对比,差异具有统计学意义(P<0.05)。结论新辅助治疗同期放化疗在直肠癌患者的治疗中应用效果更好,能有效提升患者治疗效果且提升患者术中肛门保留率。

Objective To study the application and the effect of neoadjuvant treatment of rectal cancer.Methods70 cases of patients were divided into two groups. Control group （35 cases） were given neoadjuvant radiotherapy alone, the observation group （35 cases） were given neoadjuvant therapy in combination with radiation and chemotherapy during this period, the evaluation of the difference between two groups of treatment effect. ResultsThe effective rate of the observation group （85.7%） was higher than that of the control group （54.3%）, and the difference was statistically significant （P〈0.05）. In the observation group, the anal preservation rate was 45.71% （16/35）, the incidence of complications was 25.71% （9/35）,and the recurrence rate was 5.71% （2/35） during the follow-up period; In the control group, the rate of anal preservation was 25.71% （9/35）, the incidence of complications was 22.86% （8/35）, and the recurrence rate was 8.57% （3/35） during the follow-up. In two groups of patients with anal preservation rate, the difference was statistically signiifcant （P〈0.05）. ConclusionNeoadjuvant chemotherapy in the treatment of rectal cancer patients with the same period of the application effect is better, which can effectively improve the patient to treat the effect and enhance the patient in the anus retention rate.