摘要
目的探讨肠杆菌科细菌ESBLs和AmpC酶检测及耐药性。方法选取300株肠杆菌,AmpC酶、ESBLs表型通过双纸片确诊试验、双纸片氯唑西林增效试验予以测定,观察300株菌种对10种抗菌药物的耐药性。结果 300株肠杆菌中检测到ESBLs菌158株,Amp C酶菌130株;单产AmpC酶菌对头孢曲松、氨曲南、哌拉西林、头孢噻肟产生的耐药性明显低于非产酶菌,差异具有统计学意义(P<0.05)。结论 ESBLs和AmpC酶是造成肠杆菌细菌产生耐药的重要原因,可依照实际药敏结果采取合理治疗。
Objective To study the enterobacteriaceae bacteria ESBLs and AmpC enzyme detection and drug resistance.Methods Chose 300 strains of intestinal bacilli, AmpC enzyme, ESBLs phenotype by double disc conifrmatory test, observation of 300 strains bacteria resistance of 10 kinds of antimicrobial agents.Results 300 strains of intestinal bacilli detected in ESBLs 158 strains bacteria, AmpC enzyme 130 strains bacteria; The yield of AmpC enzyme bacteria resistance to ceftriaxone, aztreonam, cefotaxime and cefotaxime have signiifcantly lower than that of enzyme producing bacteria, the difference was statistically signiifcant （P〈0.05）.ConclusionESBLs and AmpC enzyme is the important cause of bacteria resistance, can be in accordance with the actual drug susceptibility results take reasonable treatment.
出处
《中国继续医学教育》
2016年第25期175-176,共2页
China Continuing Medical Education
