摘要
尼可地尔(Nicorandil)是第一个用于临床的具有硝酸酯类作用的离子通道开放剂,能够抑制Ca2+流入细胞以及促进K+的流出,从而促进血管平滑肌的舒张以及冠状动脉的扩张,因此在临床上将尼可地尔广泛用于治疗冠心病。尼可地尔能够改善稳定性及不稳定性心绞痛患者的生活质量,延长患者的生存时间。本文综合了国内外对尼可地尔的临床应用进行研究,对临床上使用尼可地尔治疗冠心病、保护心肌及改善预后具有指导意义。
Nicorandil is a potassium channel opener with nitrate effect,which was first used in clinical and it could inhibit the Ca2＋ input and promote the K＋ output to promote vascular smooth muscle relaxation and the expansion of coronary artery,so nicorandil was widely used in the treatment of coronary heart disease clinicaly. Nicorandil can significantly improve the quality of life and prolong survival time of patients with stable and unstable angina. This＆amp;nbsp;paper combines the research of nicorandil s clinical application to review and it has guiding significance to treat coronary heart disease,myocardial protection and improve the prognosis.
出处
《中国卫生标准管理》
2016年第17期93-95,共3页
China Health Standard Management
关键词
尼可地尔
药理作用
冠心病
Nicorandil
Pharmacological effects
Coronary heart disease
