阿托伐他汀辅助治疗冠心病的疗效及对血脂和血液流变学的意义

Efficacy of atorvastatin in the treatment of coronary heart disease and its significance in blood lipid and hemorheology

目的:研究阿托伐他汀辅助治疗冠心病的疗效及对血脂和血液流变学变化的意义。方法:将我院收治的70例冠心病患者随机分为观察组和对照组各35例,对照组在常规治疗基础上加用曲美他嗪口服治疗4周;观察组在对照组基础上加用阿托伐他汀口服治疗4周。比较两组患者治疗效果及血脂和血液流变学指标变化。结果:观察组患者治疗总有效率94.3%显著高于对照组治疗总有效率77.1%(P<0.05);两组患者治疗后TC、TG、LDL-C、ηph、ηpl、ηp及Hct水平均较治疗前显著下降(P<0.01),HDL-C水平较治疗前显著升高(P<0.01)且治疗后观察组患者TC、TG、LDL-C、ηph、ηpl、ηp及Hct水平显著低于对照组(P<0.01),HDL-C水平显著高于对照组(P<0.01)。结论:阿托伐他汀辅助治疗冠心病具有良好疗效,且能显著改善血脂及血液流变学指标,值得临床推广应用。

Objective： To study the effect of atorvastatin on coronary heart disease （CHD） and its significance in the change of blood lipid and hemorheology. Methods： 70 patients with Ct-ID treated in our hospital were ran- domized into the observation group and control group with 35 cases in each group. The observation group were administered additional oral atorvastatin for 4 weeks on the basis of 4-week conventional treatment combined with oral trimetazidine treatment for the observation group. Then the treatment effect and index changes of blood lipid and hemorheology between both groups were compared. Results： The total effective rate of the observation group was 94.3%, significantly higher than 77.10/0 in the control group （ P〈0.05）; after the treatment, TC, TG, LDL-C,η ph, η pl, ηq p and Hct of both groups decreased compared with those before the treatment （ P 〈0.01）; the level of HDL-C significantly increased （ P 〈 0.01） and after treatment, TC, TG, LDL-C, η ph, η pl, η p and Hct and HCT levels in the observation group was significantly lower than those of the control group （ P〈 0.01）,I-IDL-C level was significantly higher than that of the control group （ P〈 0.01）. Conclusion： Atorvastafin auxilia- ry treatment of CHD has a better effect, and can significantly improve the indicators of blood lipids and blood rhe- ology, it is worthy of clinical application.