期刊文献+

蛋白质组学及其在脑出血研究中的进展

下载PDF
导出
摘要 蛋白质组学是揭示蛋白质功能与细胞生命活动规律的学科,它揭示疾病的发病机制、发现疾病的特异标志蛋白和寻找疾病治疗的药物靶点。蛋白质组学包括双向电泳、质谱、蛋白质芯片等技术,推动了肿瘤学、神经病学等众多领域的发展。脑出血后脑组织、脑脊液等蛋白质组学研究推动了脑出血的早期诊断、治疗甚至康复。
出处 《继续医学教育》 2016年第9期95-96,共2页 Continuing Medical Education
基金 国家自然科学基金资助项目(30973107)
  • 相关文献

参考文献18

  • 1Tsai CF,Thomas B, Sudlow CL. Epidemiology of stroke and itssubtypes in Chinese vs white populations : a systematic review[J].Neurology, 2013, 81 ( 3 ) : 264-272.
  • 2徐菲菲,刘秀华.蛋白质组学技术进展及其在微循环研究中的应用[J].生理科学进展,2010,41(6):429-434. 被引量:3
  • 3刘志广,康慧聪,朱遂强.蛋白组学相关技术在神经系统疾病研究中的进展[J].神经损伤与功能重建,2012,7(1):55-58. 被引量:2
  • 4Picotti P, Clement-Ziza M,Lam H,et al. A complete mass-spectrometric map of the yeast proteome applied to quantitative traitanalysis [J]. Nature, 2013, 494 ( 7436 ) : 266-270.
  • 5Jungblut PR , Zimny-Arndt U, Zeindl-Eberhart E , et al.Proteomics in human disease : cancer, heart and infectious diseases[J].Electrophoresis, 1999,20 ( 10 ) : 2100-2110.
  • 6Aebersold R, Mann M. Mass spectrometry-based proteomics[J].Nature, 2003,422 ( 6928 ) : 198-207.
  • 7O'Farrell PH. High resolution two-dimensional electrophoresis ofproteins|J].JBiol Chem, 1975, 250 ( 10) : 4007-4021.
  • 8Padron G, Domont GB. Two decades of proteomics in LatinAmerica : a personal view[J]. J Proteomics, 2014 ( 107 ) : 83-92.
  • 9Gembitsky DS, Lawlor K , Jacovina A, et al. A prototypeantibody microarray platform to monitor changes in protein tyrosinephosphorylation[J].Mol Cell Proteomics, 2004,3 ( 11 ) : 1102-1118.
  • 10Rodriguez M, Li SS, Harper JW, et al. An oriented peptide arraylibrary ( OPAL ) strategy to study protein-protein interactions[J]. JBiol Chem, 2004, 279 ( 10 ) : 8802-8807.

二级参考文献77

  • 1李凌云,秦正红,梁中琴.丙戊酸盐的神经保护作用及其机制的研究进展[J].中国药理学通报,2007,23(3):295-298. 被引量:22
  • 2Abbott A.And now for the proteome.Nature,2001,409:747.
  • 3Fields S.Proteomics.Proteomics in genomeland.Science,2001,291:1221- 1224.
  • 4O' Farrell PH.High resolution two-dimensional electrophoresis of proteins.J Biol Chem,1975,250:4007-4021.
  • 5Unlü M,Morgan ME,Minden JS.Difference gel electrophoresis:a single gel method for detecting changes in protein extracts.Electrophoresis,1997,18:2071-2077.
  • 6Jensen PK,Pasa-Toli L,Anderson GA,et al.Probing proteomes using capillary isoelectric focusing-electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry.Anal Chem,1999,71:2076-2084.
  • 7Lu L,Yang PY,Rui YCh,et al.Comparative proteome analysis of rat brain and coronary microvascular endothelial cells.Physiol Res,2007,56:159-168.
  • 8Lu Q,Murugesan N,Macdonald JA,et al.Analysis of mouse brain microvascular endothelium using immuno-laser capture microdissection coupled to a hybrid linear ion trap with Fourier transform-mass spectrometry proteomics platform.Electrophoresis,2008,29:2689-2695.
  • 9Mustafa DA,Burgers PC,Dekker LJ,et al.Identification of glioma neovascularization-related proteins by using MALDI-FTMS and nano-LC fractionation to microdissected tumor vessels.Mol Cell Proteomics,2007,6:1147-1157.
  • 10Park HJ,Kim BG,Lee SJ,et al.Proteomic profiling of endothelial cells in human lung cancer.J Proteome Res,2008,7:1138-1150.

共引文献7

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部