和肽素联合NT-proBNP对慢性心力衰竭患者严重程度及近期预后的相关性分析

Analysis of correlation between severity and short-term prognosis by copeptin combined with N-terminal pro-brain natriuretic peptide for chronic heart failure patients

目的观察和肽素联合N末端脑钠肽前体(NT-pro BNP)对慢性心力衰竭(CHF)患者严重程度及近期预后的相关性分析。方法 80例CHF患者作为CHF组,40例健康体检者作为对照组,两组均行和肽素以及NT-pro BNP检查,比较CHF组与对照组和肽素以及NT-pro BNP的水平差别,不同NHYA心功能分级患者两指标的变化,根据患者随访结果再次分为事件组和非事件组,并进行组间两指标的比较。结果 CHF组患者和肽素与NT-pro BNP水平(4497.50±1564.31)、(6970.10±1054.33)pg/ml明显高于对照组(1306.42±94.72)、(124.06±33.55)pg/ml(P<0.05);随着心功能分级的升高,患者和肽素水平和NT-pro BNP水平也明显升高(P<0.05);事件组患者和肽素水平和NT-pro BNP水平(4579.82±1153.43)、(8143.66±2202.17)pg/ml明显高于非事件组(2054.73±984.65)、(944.83±157.26)pg/ml(P<0.05)。结论和肽素联合NT-pro BNP检测有助于临床医生对CHF患者的病情严重程度以及预后情况做出早期预测,对于疾病诊断以及治疗具有重要意义。

Objective To observe correlation between severity and short-term prognosis by copeptin combined with N-terminal pro-brain natriuretic peptide（NT-pro BNP） for chronic heart failure（CHF） patients. Methods There were 80 CHF patients as CNF group and 40 healthy people as control group. Both groups received copeptin and NT-pro BNP detection, and their differences in copeptin and NT-pro BNP levels were compared, along with level changes in different NYHA cardiac functional classification. The patients were further divided by follow-up outcome into event group and non-event group for comparison of the two indexes. Results CHF group had obviously higher copeptin and NT-pro BNP levels as（4497.50±1564.31） and（6970.10±1054.33） pg/ml than（1306.42±94.72） and（124.06±33.55） pg/ml in the control group（P〈0.05）. Higher cardiac functional classification led to much higher copeptin and NT-pro BNP levels in patients（P〈0.05）. The event group had much higher copeptin and NT-pro BNP levels as（4579.82±1153.43） and（8143.66±2202.17） pg/ml than（2054.73±984.65） and（944.83±157.26） pg/ml in the non-event group（P〈0.05）. Conclusion Combined detection of copeptin and NT-pro BNP is helpful for early prediction of severity and prognosis of CHF patients, and this method contains important significance for diagnosis and treatment of disease.