三种阿片类镇痛药治疗重度癌痛的成本效果分析

Analysis of cost effectiveness by three oripavine analgesic agents in the treatment of severe cancer pain

目的比较盐酸吗啡缓释片、硫酸吗啡缓释片和盐酸羟考酮控释片治疗癌痛的经济学效果。方法 210例初治重度癌痛患者随机分为A、B、C三组,各70例。A组给予盐酸吗啡缓释片,B组给予硫酸吗啡缓释片,C组给予盐酸羟考酮控释片。治疗28 d,观察三组疗效、不良反应,并进行药物经济学成本效果分析。结果三组疼痛缓解率分别为88.6%、90.0%、91.4%,比较差异无统计学意义(P>0.05);三组不良反应发生情况比较差异无统计学意义(P>0.05);三组成本效果比(C/E)分别为(15.44±8.53)、(16.37±8.48)和(25.98±8.07)。结论盐酸吗啡缓释片、硫酸吗啡缓释片和盐酸羟考酮控释片用于癌痛患者疗效相当,盐酸吗啡缓释片治疗癌痛较经济。

Objective To compare cost effectiveness by morphine hydrochloride sustained-release tablets, morphine sulfate sustained-release tablets and oxycodone hydrochloride sustained-release tablets in the treatment of cancer pain. Methods A total of 210 patients with severe cancer pain were randomly divided into groups A, B and C, with 70 cases in each group. Group A received morphine hydrochloride sustainedrelease tablets, group B received morphine sulfate sustained-release tablets, and group C received oxycodone hydrochloride sustained-release tablets. Their treatment lasted for 28 d, and observation was made on curative effects and adverse reactions between three groups for pharmacoeconomics cost effectiveness analysis. Results There was no statistically significant difference of pain relief rates as 88.6%, 90.0% and 91.4% across the three groups（P〈0.05）. The difference of incidence of adverse reactions had no statistical significance between the three groups（P〈0.05）. Cost effectiveness ratio（C/E） in three groups was respectively（15.44±8.53）,（16.37±8.48） and（25.98±8.07）. Conclusion Morphine hydrochloride sustained-release tablets, morphine sulfate sustainedrelease tablets and oxycodone hydrochloride sustained-release tablets all provide similar curative effects in treating cancer pain, and morphine hydrochloride sustained-release tablets is more economical for treatment.