前列地尔联合甲钴胺治疗糖尿病周围神经病变临床观察

Clinical observation of alprostadil combined with mecobalamine in the treatment of diabetic peripheral neuropathy

目的探究前列地尔联合甲钴胺治疗糖尿病周围神经病变临床效果。方法 74例糖尿病周围神经病变患者,随机分为实验组与对照组,各37例。对照组采用甲钴胺注射液进行治疗,实验组采用甲钴胺注射液联合前列地尔注射液进行治疗。对比两组患者的临床治疗效果以及感觉神经传导速度等。结果实验组治疗总有效率为94.59%,显著高于对照组的64.86%(P<0.05);治疗后实验组患者感觉神经传导速度显著快于对照组(P<0.05)。结论对于糖尿病周围神经病变患者实施甲钴胺联合前列地尔治疗可以取得良好的临床效果,能够减轻患者的疼痛以及家庭经济负担。值得推广使用。

Objective To investigate clinical effect by alprostadil combined with mecobalamine in the treatment of diabetic peripheral neuropathy. Methods A total of 74 patients with diabetic peripheral neuropathy were randomly divided into experimental group and control group, with 37 cases in each group. The control group received mecobalamine injection for treatment, and the experimental group received mecobalamine combined with alprostadil injection. Comparison was made on clinical effects and sensory nerve conduction velocity between the two groups. Results The experimental group had obviously higher total effective rate as 94.59% than 64.86% of the control group（P〈0.05）, and the experimental group had much faster sensory nerve conduction velocity than the control group（P〈0.05）. Conclusion Implement of mecobalamine combined with alprostadil can provide good clinical effect in treating diabetic peripheral neuropathy patients. This method can relieve pain in patients and lower financial cost, and it is worth promoting and applying.