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小剂量左甲状腺素治疗良性甲状腺结节的疗效探讨 被引量:15

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摘要 目的探讨小剂量左甲状腺素治疗良性甲状腺结节的应用效果。方法 90例良性甲状腺结节患者给予小剂量左甲状腺素治疗。记录患者治疗前后各项甲状腺激素水平[游离甲状腺素(FT_4)、游离三碘甲状腺原氨酸(FT_3)、促甲状腺素(TSH)]变化情况及不良反应发生率。结果治疗前,TSH(2.67±0.79)m U/L、FT_4(104.25±20.45)nmol/L、FT_3(1.90±0.44)nmol/L;治疗后TSH(2.01±0.56)m U/L、FT_4(109.28±23.08)nmol/L、FT_3(2.10±0.43)nmol/L。治疗后患者TSH水平得到显著降低,而FT_4、FT_3水平则显著升高,差异有统计学意义(P<0.05);仅8例(8.89%)发生药物相关不良反应。结论对良性甲状腺结节患者给予小剂量左甲状腺素治疗效果满意,可有效保障患者预后及生活质量。
作者 刘芳
出处 《中国实用医药》 2016年第25期153-154,共2页 China Practical Medicine
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  • 1Sdano MT, Falciglia M, Welge JA, et al. Efficacy of thyroid hormone suppression for benign thyroid nodules: meta-analysis of randomized trials[J]. Otolaryngol Head Neck Surg, 2005, 133(3):391-396.
  • 2Costante G, Crocetti U, Schifino E, et al. Slow growth of benign thyroid nodules after menopause: no need for long-term thyroxine suppressive therapy in post-menopausal women[J]. J Endocrinol invest, 2004, 27(1):31-36.
  • 3Cesareo R, Iozzino M, Isgro MA, et al. Short term effects of levothyroxine treatment in thyroid muhinodular disease[J]. Endocr J, 2010, 57(9):803-809.
  • 4Fagin JA, Mitsiades N. Molecular pathology of thyroid cancer: diagnostic and clinical im?plications [Jl. Best Pract Res Clin Endocri?nol Metah, 2008, 22 (6): 955 -969.
  • 5Papini E, Guglielmi R, Bianchini A, et al. Risk of malignancy in nonpalpahle thyroid nod?ules: predictive value of ultrasound and color - Doppler features [J]. J Clin Endocrinol Metah, 2002, 87 (5): 1941 -1946.
  • 6Iyer NG, Shaha AR. Management of thyroid nodules and surgery for differntiated thyroid cancer [J]. Clin Oncol (R Coil Radiol), 2010, 22 (6): 405 -412.
  • 7Alexander EK, Hurwitz S, Heering JP, et al. Natural history of benign solid and cystic thyroid nodules [J]. Ann Intern Med, 2003, 138 (4): 315 -318.
  • 8Gharib H. Fine needle aspiration biopsy of thyroid nodules: advantages, limitations and effect [J]. Mayo Clin Proc , 1994 , 69 (1): 44 -49.
  • 9Wojtczak B, Sutkowski K, Bolanowski M, et al. The prognostic value of fine - needle aspiration biopsy of the thyroid gland - analy?sis of results of 1078 patients [J]. Neuro Endocrinol Lett, 2012, 33 (5): 511 - 516.
  • 10Grussendorl M, Reiners C, Paschke R, et al. Reduction of thyroid nodule volume by levothyroxine and iodine alone and in combi?nation: a randomized, placebo - controlled trial [J]. J Clin Endocrinol Metab, 2011, 96 (9): 2786 -2795.

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