冠心病PCI术后应用参七汤对冠脉再狭窄的临床预防干预效果观察

Clinical Prevention and Intervention Effect of Shenqi Decoction on Coronary Restenosis of Coronary Heart Disease After PCI

目的:观察冠心病PCI术后患者应用参七汤对冠脉再狭窄的临床预防干预效果。方法:我院收治的218例冠心病患者按照随机数字表法分为研究组和对照组,每组109人。对照组给予西医常规治疗。研究组在对照组方案上加用参七汤。对比2组治疗前后中医证候积分、炎性反应指标的变化,对比冠脉再狭窄发生率。结果:研究组在服药3个月及服药6个月时的气虚证候积分及血瘀证候积分下降幅度显著优于同期的对照组(P<0.05)。研究组服药3个月及服药6个月后的超敏C-反应蛋白、活化T淋巴细胞、可溶性白细胞介素-2受体水平均显著优于同期对照组(P<0.05)。研究组再狭窄发生率为17.43%,显著低于对照组的34.86%(P<0.05)。结论:冠心病PCI术后应用参七汤可显著优化患者的中医证候,遏制患者体内的慢性炎性反应状态,提升免疫水平,降低冠脉再狭窄风险。

Objective：To observe the clinical prevention and intervention effect of Shenqi decoction on coronary restenosis of pa-tients with coronary heart disease after PCI.Methods：A total of 218 patients with coronary heart disease treated in this hospital were divided into the research group and control one according to the random number table,with 109 cases in each group.Patients in the control group were given the routine western medicine therapy;while patients in the research group were given the treatment of Shenqi decoction in addition to the routine western medicine therapy.The changes of TCM syndrome scores and changes of in-flammatory markers before and after the treatment and incidence of coronary restenosis were compared between two groups.Re-sults：The magnitude of decrease in qi deficiency symptom score and blood stasis syndrome score of patients at 3 months and 6 months after taking the medicine in the research group were significantly better than those in the control group （P 〈0.05）.The levels of high-sensitivity C-reactive protein,activated T lymphocytes and soluble interleukin-2 receptor at 3 months and 6 months af-ter the treatment the treatment in the research group were significantly better than those in the control group （P 〈0.05）.The inci-dence of restenosis for patients in the research group was 17.43%,which was significantly lower than 34.86% of control group （P〈0.05）.Conclusion：The application of Shenqi decoction in the coronary heart disease after PCI can significantly improve the TCMsyndrome scores of patients,inhibit the chronic inflammatory state,enhance the immunity levels and reduce the risk of coro-nary restenosis.