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结直肠腺瘤与结直肠癌患者血清瘦素、脂联素及抵抗素的相关性研究 被引量:2

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摘要 目的研究结直肠腺瘤性息肉与结直肠癌患者血清中瘦素、脂联素及抵抗素的相关性。方法选取经纤维结肠镜活检或切除并经病理证实的结直肠腺瘤患者37例,结直肠癌患者36例,同时选取健康对照组25例。提取血清以ELISA的方法测定血清中瘦素、脂联素及抵抗素的含量。平均BMI值也同时测定。结果 37例息肉样腺瘤患者中,高分化型25例,低分化型12例。所有结直肠癌患者皆为腺癌。高分化型息肉样腺瘤患者与低分化型息肉样腺瘤患者中,血清脂肪细胞因子含量差异无统计学意义(P>0.05)。结直肠癌患者血清中瘦素及脂联素的含量明显低于息肉样腺瘤患者(P<0.05),明显低于健康对照组(P<0.05)。结直肠癌患者血清中抵抗素含量与息肉样腺瘤患者差异无统计学意义(P>0.05),明显高于健康对照组(P<0.05)。血清中脂联素与瘦素含量具有明显相关性(r=0.61)。结论血清中脂联素与抵抗素在结肠癌变中可能起重要作用。瘦素可能对临床预后具有参考价值。
出处 《河北医药》 CAS 2016年第19期2957-2960,共4页 Hebei Medical Journal
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