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SAPHO综合征研究进展 被引量:4

Advances in SAPHO syndrome
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摘要 SAPHO综合征(synovitis-acne-pustulosis-hyperostosis-osteitis syndrome)是指由滑膜炎(synovitis)、痤疮(acne)、脓疱病(pustulosis)、骨肥厚(hyperostosis)和骨炎(osteitis)组成的一组少见的慢性无菌性炎症综合征,临床表现多样化,主要累及皮肤和骨关节,影像学可见特征性骨肥厚及骨炎。近来随着对疾病的认识增加,该病报道逐渐增多但治疗比较困难,生物制剂为SAPHO治疗提供新的选择。 SAPHO syndrome is a kind of rare chronic aseptic infl ammation characterized by synovitis, acne, pustulosis, hyperostosis and osteitis. The clinical features of SAPHO syndrome are diversified, and hyperostosis and osteitis are characteristic radiologic findings. Recently new biologic agents provide new choices for the treatment of SAPHO syndrome.
出处 《实用皮肤病学杂志》 2016年第4期256-258,共3页 Journal of Practical Dermatology
基金 上海卫生系统优秀学科带头人新百人项目(XBR2013113)
关键词 SAPHO综合征 脓疱病 痤疮 滑膜炎 骨肥厚 骨炎 SAPHO syndrome Pustulosis Acne Synovitis Hyperostosis Osteitis
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参考文献31

  • 1Nguyen MT, Borchers A, Selmi C, et al. The SAPHO syndrome [J]. Semin Arthritis Rheum, 2012, 42(3):254-265.
  • 2Chamot AM, Benhamous CL, Kahn MF, et al. Acne-pustulosis- hyperostosis-osteitis syndrome, results of a national survey. 85 cases [J]. Rev Rhum Mal Osteoartic,1987, 54(3):187-196.
  • 3Depasquale R, Kumar N, Lalam RK, et al. SAPHO:what radiologists should know [J]. Clinical radiology, 2012, 67(3): 195-206.
  • 4Kundu BK, Naik AK, Bhargava S, et al. Diagnosing the SAPHO syndrome: a report of three cases and review of literature [J]. Clin Rheumatol, 2013, 32(8):1237-1243.
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  • 7Perry A, Lambert P. Propionibacterium acnes: infection beyond the skin [J]. Expert Rev Anti Infect Ther, 2011, 9(12): 1149-1156.
  • 8Kistowska M, Gehrke S, Jankovie D, et al. IL-1β drives inflammatory responses to propioniebacterium acnes in vitro and in vivo [J]. J Invest Dermatol, 2014, 134(3):677-685.
  • 9Przepiera-Bedzak H, Fischer K, Brzosko M. Serum IL-6 and IL-23 levels and their correlation with angiogenic cytokines and disease activity in ankylosing spondylitis, psoriatic arthritis, and SAPHO syndrome [J]. Mediatiors Inflamm, 2015, 2015:785705.
  • 10Rosero A, Ruano R, Martin M, et al. Acute venous thrombosis as complication and clue to diagnose a SAPHO syndrome case [J]. Acta Reumatol Port, 2013, 38(3):203-206.

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