蔓荆子化学成分研究新进展

New Progress in the Study of Chemical Constituents of Fructus Viticis

近年研究发现二萜、黄酮、木脂素类等化合物是中药蔓荆子发挥抗癌作用的物质基础,为中药蔓荆子用于癌症治疗的民间用法提供了科学依据。其中劳丹烷型二萜1~6,黄酮7~9,11~12,和木脂素化类化合物15是新的细胞周期抑制剂,为细胞周期抑制剂提供了新的结构类型,也为抗癌药的研究提供了新的先导化合物。

Recent studies have found diterpenes, flavonoids and lignans are the material basis of the anticancer activity of Vitex trifolia. It provides a scientific basis for the use of Chinese herbal medicine in the treatment of cancer in China. Such as laudan diterpene 1~6, flavonoids 7~9, 11~12, and lignans of compound 15 is a new cell cycle inhibitor, provides a new structure type and new lead compound for anticancer drug research.