七氟烷联合瑞芬太尼麻醉在腹腔镜胆囊切除术中应用效果及安全性分析

Analysis on the Efficacy and Safety of Sevoflurane Combined with Remifentanil Anesthesia in Laparoscopic Cholecystectomy

目的探讨腹腔镜胆囊切除术中应用七氟烷联合瑞芬太尼的效果及安全性。方法选取我院2014年9月至2015年9月收治的腹腔镜下胆囊切除术患者80例为研究对象,随机将其分为研究组和常规组各40例。常规组给予丙泊酚联合瑞芬太尼全凭静脉麻醉,研究组给予七氟烷联合瑞芬太尼静吸复合麻醉,观察两组患者术后苏醒质量、麻醉效果及血流动力学指标。结果研究组苏醒时间和拔管时间均明显短于常规组(P<0.05);研究组拔管后苏醒评分明显高于常规组(P<0.05);研究组麻醉总有效率为97.50%,明显高于常规组的52.50%(P<0.05);研究组围手术期HR、SBP、DBP波动较常规组弱,组间差异有统计学意义(P<0.05)。结论七氟烷联合瑞芬太尼的麻醉效果更为显著且安全性高,更适用于腹腔镜下胆囊切除术,值得临床应用与推广。

Objective To explore the efficacy and safety of sevoflurane combined with remifentanil in laparoscopic cholecystectomy.Methods 80 cases of patients treated with laparoscopic cholecystectomy admitted to our hospital from September 2014 to September 2015were randomly and equally divided into study group and conventional group. The conventional group was given total intravenous anesthesiawith propofol and remifentanil. The study group was given inhalation anesthesia with sevoflurane and remifentanil. The postoperativerecovery quality, anesthesia effect and hemodynamic indexes of two groups were observed. Results The recovery time and extub timeof study group were significantly shorter than those of conventional group （P 〈0.05）. The recovery score afer extubation of study group wassignificantly higher than that of conventional group （P 〈0.05）. The total effective rate of study group was 97.50%, significantly higher than52.50% of conventional group （P〈0.05）. The HR, SBP and DBP fluctuation in perioperative period in study group were weaker than those inconventional group, with statistical difference （P 〈0.05）. Conclusions The anesthesia effect of sevoflurane combined with remifentanil ismore significant with high safety, which is more suitable for laparoscopic cholecystectomy and worthy of clinical application and promotion.