还原型谷胱甘肽联合复方甘草酸苷治疗药物性肝病的临床疗效

Clinical Effect of Glutathione Combined with Compound Glycyrrhizin in the Treatment of Drug-Induced Liver Disease

目的探讨采用还原型谷胱甘肽联合复方甘草酸苷治疗药物性肝病的临床效果。方法选取我院收治的药物性肝病患者80例,随机平均分成两组。对照组采用益肝灵进行治疗,研究组在对照组的治疗基础上加用还原型谷胱甘肽联合复方甘草酸苷治疗。治疗结束后对两组患者的治疗效果与肝功能情况进行比较分析。结果研究组治疗后的总有效率明显高于对照组,差异具有统计学意义(P<0.05)。两组治疗后的ALT、AST、TBIL等指标均显著降低,其中研究组的指标在治疗后显著低于对照组,差异均存在统计学意义(P<0.05)。结论采用还原型谷胱甘肽联合复方甘草酸苷治疗药物性肝病疗效显著,可有效促进患者肝功能的改善,值得推广。

Objective To explore the clinical effect of glutathione combined with compound glycyrrhizin in the treatment ofdrug-induced liver disease. Methods A total of 80 cases of patients with drug-induced liver disease admitted to our hospital were randomlydivided into two groups equally. The control group was treated with Yiganling, while the study group was treated with glutathione combinedwith compound glycyrrhizin on this basis. After the treatment, the treatment effect and liver function of two groups were compared andanalyzed. Results After the treatment, the total effective rate of study group was significantly higher than that of control group, withstatistical difference （P 〈0.05）. After the treatment, the ALT, AST and TBIL of two groups all decreased significantly, and the ilLeS ofstudy group were significantly lower than those of control group, with statistical differences （P 〈0.05）. Conclusions Glutathione combinedwith compound glycyrrhizin has significant curative effect in the treatment of drug-induced liver disease, and can effectively improvepatients＇ liver function, which is worthy of promotion.