重症急性胰腺炎采用不同剂量奥曲肽治疗的效果和安全性分析

Effect and Safety Analysis of Different Doses of Octreotide in the Treatment of Severe Acute Pancreatitis

目的探讨采用不同剂量奥曲肽治疗重症急性胰腺炎的效果和安全性。方法选取我院治疗的重症急性胰腺炎患者50例,随机平均分为对照组和观察组。两组患者入院后均予以禁食、胃肠减压、消化腺分泌抑制、抗感染、纠正水电解质紊乱等常规治疗,对照组在常规治疗基础上予以奥曲肽0.6 mg/d静脉滴注治疗,观察组予以奥曲肽1.2 mg/d静脉滴注,治疗时间均为1周。观察并对比两组患者相关症状消失时间、药后不良反应发生率和总有效率。结果观察组的相关症状消失时间显著短于对照组(P<0.05)。治疗后两组的不良反应发生率比较差异无统计学意义(P>0.05)。观察组的治愈率和总有效率分别为32.00%、92.00%,显著高于对照组的12.00%、68.00%,差异均具有统计学意义(P<0.05)。结论 1.2 mg/d剂量的奥曲肽在治疗重症急性胰腺炎方面具有较好的临床效果和较高的安全性,值得临床推广应用。

Objective To explore the effect and safety of different doses of octreotide in the treatment of severe acute pancreatitis.Methods 50 cases of patients with severe acute pancreatitis admitted to our hospital were selected and randomly divided into control groupand observation group equally. Both groups received conventional treatment, such as fasting, gastrointestinal decompression, inhibition ofthe secretion of digestive gland, anti-infection, and correction of water and electrolyte disorders; In addition, the control group received 0.6mg/d octreotide for intravenous drip, while the observation group received 1.2 mg/d octreotide for intravenous drip. The duration oftreatment was one week in both groups. The disappearance time of symptoms, incidence of adverse reactions and total effective rate of twogroups were observed and compared. Results The disappearance time of symptoms of observation group was significantly shorter than thatof control group （P〈0.05）. No statistical difference was found between two groups in the incidence of adverse reactions （P 〉0.05）. The curerate and total effective rate of observation group were respectively 32.00% and 92.00%, significantly higher than 12.00% and 68.00% ofcontrol group, with statistical differences （P〈0.05）. Conclusions The dose of 1.2 mg/d of octreotide in treatment of severe acute pancreatitishas better clinical effect and higher safety, which is worthy of clinical promotion and application.