化瘀尿石汤对肾结石患者体外碎石术后肾损伤的影响

Effect ofHuayu-Niaoshidecoction on renal injury in the patients with kidney stones after extra corporeal lithotripsy

目的：探讨化瘀尿石汤对肾结石患者体外碎石术后肾损伤的影响。方法将符合入选标准的120例肾结石患者按随机数字表法分为2组，每组60例。2组均采用复式脉冲体外冲击波碎石，对照组于碎石当日开始服用甲磺酸左氧氟沙星片，连续服用3 d；治疗组在对照组基础上加服化瘀尿石汤14 d。分别于碎石前、碎石当日，碎石后2周检测血清内皮素1（Endothelin-1, ET-1）、MDA，同时留取尿液检测尿N-乙酰-β-D-氨基葡萄糖苷酶（N-acetyl-β-D-glucosa minidase, NAG）、尿β2微球蛋白（β2-microglobulin,β2-MG）。结果碎石后2周，治疗组尿NAG[（7.33±4.39）U/L比（9.93±5.10）U/L；Z＝2.587，P＝0.002]、血清 MDA[（4.63±0.90）nmol/ml 比（7.29±2.16）nmol/ml；Z＝5.520，P＝0.001]、血清 ET-1[（35.06±10.51）pg/ml 比（46.90±18.74）pg/ml；Z＝3.315， P＝0.001]、尿β2-MG[（0.14±0.17）mg/L 比（0.19±0.19）mg/L；Z＝1.759，P＝0.079]水平均低于对照组。结论化瘀尿石汤可改善肾结石体外碎石患者碎石后2周时血清MDA、ET-1水平及尿NAG、β2-MG水平，对肾结石体外碎石患者的肾损伤有修复作用。

ObjectiveTo investigate the effect ofHuayu-Niaoshidecoction on renal injury in the patients with kidney stones after extra corporeal lithotripsy （ESWL）. MethodsAccording to the inclusion criteria, 120 patients diagnosed with kidney stones were randomly divided into 2 groups with the random number table method, 60 patients in each group. Both groups were treated with double pulse extracorporeal shock wave lithotripsy （ESWL）. Based on the ESWL, the control group was added with levofloxacin mesylate tablets for 3 days with the start of the day of the gravel; and the treatment group was treated withHuayu-Niaoshi decoction for 14 days based on the treatment of control group. The levels of serum endothelial endothelin 1 （ET-1）, malondialdehyde （MDA）, urinary N-acetyl-β-Dglucosaminidase （NAG） N-acetyl-beta-d Glucosaminidase and urine beta 2 microspheres protein （beta eukaryotic 2-mg） were detected at time of gravel, 2 hours after gravel and 2 weeks after gravel. ResultsAfter 2 weeks treatment, the levels of urinary NAG （7.33 ± 4.39 U/L vs. 9.93 ± 5.10 U/L;Z=2.587,P=0.002）, serum MDA （4.63 ± 0.90 nmol/mlvs. 7.29 ± 2.16 nmol/ml;Z=5.520, P=0.001）, serum ET-1 （35.06 ± 10.51 pg/mlvs. 46.90 ± 18.74 pg/ml;Z=3.315,P=0.001） and urineβ2-MG （0.14 ± 0.19） mg/Lvs. 0.19 ± 0.19 mg/L;Z=1.759,P=0.079） in the treatment group were significantly lower than those in the control group. Conclusions TheHuayu-Niaoshidecoction can improve renal injury in the patients with 〈br〉 kidney stones after extra corporeal lithotripsy.