摘要
Stewart于1979年提出降压过度,尤其是舒张压降得过低可能增加心血管疾病并发症风险。此后大量研究逐渐证实了舒张压与心血管疾病之间存在J型曲线关系,并且这种关系同样体现在合并冠心病、糖尿病的高血压患者以及老年高血压患者中。因此,强化降压的理念受到了巨大的冲击,尤其是不同人群中究竟该如何选择降压目标值,再一次成为了临床医生们面临的难题。现在分析归纳一些大型临床试验的结果,对降压过程中低舒张压与心血管疾病的关系做一综述。
During the past 3 decades, the J-emwe relationship between diastolic blood pressure （DBP）and cardiovascular disease （CVD） has been a subject of much concern. Numerous studies have provided strong evidence for J-curve relationship between DBP and CVD in the general hypertensive patients, as well as in high-risk populations,including patients with coronary artery disease,diabetes mellitus and the elderly. As a result aggressive blood pressure-lowering has been impacted and physicians are once again stuck for what to choose as a target level. This paper analyzed the result of a few large clinical trials and reviewed the J-curve relationship between DBP and CVD to provide a basis for rational antihypertensive therapy.
出处
《心血管病学进展》
CAS
2016年第5期486-490,共5页
Advances in Cardiovascular Diseases
基金
国家自然科学基金(2016-gz19)
关键词
舒张压
心血管疾病
J型曲线
降压治疗
Diastolic blood pressure
Cardiovascular disease
J-curve relationship
Antihypertensive therapy
