免疫固定电泳技术诊断及分型多发性骨髓瘤的临床研究

Clinical study of immunofixation electrophoresis in the diagnosis and typing of multiple myeloma

目的研究分析免疫固定电泳技术诊断及分型多发性骨髓瘤的效果。方法 回顾性分析我院于2015年5月-2016年5月收治的60例多发性骨髓瘤患者的病历资料,作为观察组,同时选择免疫球蛋白相同的健康体检者作为对照组,共40例,所有研究对象均进行免疫固定电泳技术诊断,同时采用西门子BNII免疫分析仪测定血清免疫球蛋白含量并进行分析。结果 160例多发性骨髓瘤患者经过免疫固定电泳技术诊断之后,其中54例阳性,符合率为90%。2多发性骨髓瘤的Ig A、Ig G、Ig M与对照组比较,差异有统计学意义（P〈0.05）。轻链型组血清免疫球蛋白含量与对照组比较,差异无统计学意义（P〉0.05）。结论 多发性骨髓瘤应用免疫固定电泳技术有着较高的诊断价值和分型意义,值得临床推广应用。

Objective To study and analyze the effects of immunofixation electrophoresis in the diagnosis and typing of multiple myeloma. Methods Medical records of 60 patients with multiple myeloma who were admitted to our hospital from May 2015 to May 2016 were retrospectively analyzed, and were assigned to the observation group. The healthy subjects with the same immunoglobulin were selected at the same time as the control group, with a total of 40 subjects. The patients were all diagnosed by immunofixation electrophoresis, and quantitative immunoglobulin of the two groups was tested at the same time, and was analyzed by Siemens BNII immunoassay analyzer. Results ①Among the 60 patients with multiple myeloma who were diagnosed by immunofixation electrophoresis, 54 patients were positive, with the accor- dance rate of 90%. ②There were statistically significant differences of IgA, IgG and IgM in the research group com- pared with those in the control group（P〈0.05）. The difference of the content of serum immunoglobulin in the light- chain type compared with that in the control group was not statistically significant（P〉0.05）. Conclusion Application of immunofixation electrophoresis in the treatment of multiple myeloma has relatively higher diagnostic value and typing significance, which is worthy of clinical promotion and application.