IL-23和PG-1水平在不同胃部疾病患者体内的临床表达意义

Significance of clinical expression of IL-23 and PG-1 levels in the patients with different gastric diseases

目的分析白细胞介素-23和胃蛋白酶原-1水平在不同胃部疾病患者体内的临床表达意义,为不同胃部疾病的早期鉴别提供参考依据。方法以187例胃部疾病患者为研究对象,按其诊断结果进行分组,检测患者胃组织IL-23表达及血清IL-23、PG-1表达,分析其相关性及临床表达意义。结果 CAG组病变组织IL-23水平高于CSG组,GC组病变组织IL-23水平高于CAG组(P<0.05);CSG组织中IL-23为弱阳性表达,而CAG、GC组织中IL-23均为强阳性表达。CAG组血清IL-23水平高于CSG组,GC组血清IL-23水平高于CAG组(P<0.05);CAG组血清PG-1水平低于CSG组,GC组血清PG-1水平低于CAG组,差异有统计学意义(P<0.05)。CSG组(r=-0.470)、CAG组(r=-0.524)、GC组(r=-0.751)患者血清IL-23与PG-1均呈负相关(P<0.05)。结论随着胃部疾病的进展,患者病变组织及血清IL-23水平逐渐升高,血清PG-1水平逐渐降低,根据患者病变组织及血清IL-23变化及IL-23/PG-1比值有望提高胃癌及癌前病变的早期检出率。

Objective To analyze the significance of clinical expression of interleukin 23 （IL-23） and pepsinogen 1 （PG-1） in the patients with different gastric diseases, so as to provide references for the early identification of different gastric diseases. Methods 187 patients with gastric diseases were selected as research subjects. According to their di- agnostic results, the patients were assigned to groups. IL-23 expression and serum IL-23 and PG-1 expression in the gastric tissues in the patients were tested, and their relevance and significance of clinical expression were analyzed. Results IL-23 level of the pathological tissues in the CAG group was higher than that in the CSG group, and IL-23 level of the pathological tissues in the GC group was higher than that in the CAG group （P〈0.05）; the expression of IL- 23 in the CSG tissues was weakly positive, and the expression of IL-23 in CAG and GC tissues was strongly positive. Serum IL-23 level in CAG group was higher than that in the CSG group, and serum IL-23 level in the GC group was higher than that in the CAG group（P〈0.05）; serum PG-1 level in the CAG group was lower than that in the CSG group, and serum PG-1 level in the GC group was lower than that in the CAG group. The differences were statistically signifi- cant （P〈0.05）. Serum IL-23 was negatively correlated with PG-1 in the patients in CSG group （r=-0.470）, CAG group （r=-0.524） and GC group （r=-0.751）（P〈0.05）. Conclusion With the progression of gastric diseases, IL-23 levels in the pathological tissues and serum in the patients are gradually increased, and the serum PG-1 level was gradually re- duced. According to the changes of pathological tissues and serum IL-23, as well as IL-23/PG-1 ratio, early detection rate of gastric cancer and precancerous lesion is expected to be increased.