新疆地区维吾尔族与哈萨克族酒精依赖患者幽门螺杆菌感染的多因素研究

Multi-factor research of helicobacter pylori infection in Uyghur and Kazak patients with alcohol dependence in Xinjiang Area

目的通过对新疆地区维吾尔族与哈萨克族酒精依赖患者幽门螺杆菌（Hp）感染的多因素研究,找出在新疆地区维族与哈族酒精依赖患者的Hp感染的病因线索。方法 采用一般情况调查问卷和酒精使用障碍筛査量表（Alcohol Use Disorders Identification Test）对2014年9月-2015年8月符合入组的220例（其中维族108例、哈族112例）酒精依赖患者进行Hp感染的多因素研究。对两民族之间饮酒频率及饮酒年限等多个计数资料Hp感染率的比较采用χ^2检验,不同年龄、不同文化程度等级资料的比较采用秩和检验,对Hp感染率与多个因素的关系采用多因素Logistic回归分析结果。结果 两组酒精依赖患者中Hp总感染率为82.7%。多因素Logistic回归分析提示,与哈族比较,维族Hp感染的风险因素是哈族的0.417倍（P=0.016,OR=0.417）,饮酒年限（P=0.048,OR=1.861）与饮酒频率（P=0.044,OR=1.577）是Hp感染的危险因素。结论新疆地区维族与哈族酒精依赖患者Hp感染率明显高于全国人均水平,频繁大量饮酒可能导致Hp感染的发生。在新疆地区少数民族聚居的地方开展健康教育,建立健康生活方式,对Hp感染的预防和控制有极其重要的意义。

Objective To find out the pathogenesis of helicobacter pylori （Hp） infection in Uyghur and Kazak patents with alcohol dependence in Sinkiang area through the multi-factor analysis. Methods The general situation question-naire and alcohol use disorders identification test was adopted and multi-factor analysis of Hp infection for the 220 en- rolled patients（108 Uyghur and 112 Kazak） from September 2014 to August 2015 was performed. X2 test was adopted to compare several materials like drinking frequency, volume and years between the two nationalities. Rank sum test was adopted to compare the materials like different age, education. Multi-factor Logistic regression was adopted to analyze the correlation between the Hp infection rate and multiple factors. Results The total Hp infection rate of the patients with alcohol dependence of the two groups was 82.7%. It was suggested by the multi-factor logistic regression that the Hp infection risk of Uyghur was 0.417 times of the Kazak（P=0.016, OR=0.417） and drinking years（P=0.048, OR=1.861） and drinking frequency（P=0.044, OR=1.577） were the risk factors of Hp infection. Conclusion The Hp infection rate of Uyghur and Kazak patients with alcohol dependence was significantly higher than that of the average level of the people all over the country and frequently drinking as well as drinking large amount of alcohol may lead to the occurrence of Hp infection. The initiation of health education and establishment of healthy lifestyle in the areas inhabited by the mi- norities in Sinkiang plays important role in the prevention and control of Hp infection.