毛蕊花糖苷固体分散体制备工艺研究

Study on Preparation of Verbascoside Solid Dispersion

目的制备毛蕊花糖苷-泊洛沙姆188固体分散体,提高毛蕊花糖苷的溶出度,以提高其生物利用度。方法采用熔融法制备固体分散体,考察药物和载体的比例、熔融温度、冷却温度对溶出度的影响,比较固体分散体和物理混合物的溶出度。结果制成固体分散体的药物溶出度在一定程度上随载体比例增加而增加。当药物和载体比例达到1∶11时,药物的溶出度增大最明显。结论制备毛蕊花糖苷固体分散体的药物溶出度有显著提高。

Objective To prepare vcrbascoside-poloxamer 188 solid dispersions in order to increase the dissolution rate of verbascoside and improve its bioavailability. Methods The melting method was used to prepare solid dispersion. The effect of the ratio of the drug to poloxamer 188,melting temperature and cooling temperature were explored,and the dissolution of solid dispersion and physical mixture were compared. Results In a certain extent,with the increase of the carrier ratio ,the drug release of the prepared solid dispersions in- creased. When the ratio of the drug to poloxamer 188 rose to 1 ： 11, the dissolution rate of the drug increased most obviously. Conclusion The dissolution rate of prepared verbascoside solid dispersion has improved significantly.