战场环境封闭强化训练慢性应激致维和军人血清IL-6、TNF-α和执行功能的变化

The effects of chronic military stress on interleukin-6,tumor necrosis factor-αand executive function among peacekeeping soldiers in battlefield environment

目的探讨战场环境封闭训练慢性应激对维和军人血清白细胞介素IL-6(interleukin-6,IL-6)、肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)和执行功能的影响。方法随机选择参加南苏丹维和部队的军人41名,分别在出国前和平环境封闭训练5个月和在南苏丹战场环境中封闭训练5个月后,进行执行功能测验,包括数字符号测验、数字广度测验、词语流畅以及Stroop色词测验,并同期分别采用ELLISA进行血IL-6和TNF-α的检验。结果维和军人在战场环境下封闭训练5个月后数字符号测验得分(55.71±12.47)、数字广度测验得分(12.46±3.30)及词语流畅得分(48.49±8.07)均低于出国前和平环境中的得分(分别为62.29±10.88、14.88±2.96、49.88±8.32,均P<0.01),Stroop 1〔(67.76±15.85)s〕、Stroop 2〔(28.15±5.32)s〕计时长于其出国前和平环境中的计时〔(55.73±15.50)s、(23.05±3.72)s,均P=0.00〕。维和军人战场环摬封闭强训练5个月后的IL-6〔(204.61±94.98)ng/L〕和TNF-α〔(53.18±2.69)pg/mL〕水平高于其出国前和平环境封闭训练时水平〔分别为(144.19±72.40)ng/L和(45.01±3.61)pg/mL,均P<0.05〕,但IL-6、TNF-α均在正常范围内。结论战场环境条件下封闭训练慢性应激可能影响维和军人执行功能及血清IL-6、和TNF-α水平。

Objective To explore the effects of chronic military stress on interleukin‐6 （IL‐6） ,tumor necrosis factor‐α （TNF‐α） and executive function by confined intensive training of peace‐keeping soldiers in battlefield environment of South Sudan. Methods Fourty‐one peace‐keeping soldiers were randomly selected as the respondents. The executive function were tested after training intensely in the domestic and in South Sudan for 5 months ,respectively. The executive function included digit symbol test ,digit span test ,verbal fluency test and Stroop color words test. The levels of IL‐6 ,TNF‐α were tested by using the enzyme‐linked immunoassay （ELISA ） among peace‐keeping soldiers in corresponding periods.Results _ The peace‐keeping soldiers in battlefield environment got lower scores in the digit symbol test （55.71 ± 12.47） ,digit span test （12.46 ± 3.30） ,verbal fluency test （48.49 ± 8.07） after training intensely in South Sudan for 5 months than those in the domestic （62.29 ± 10.88 ,14.88 ± 2.96 ,49.88 ± 8.32 , P〈 0.01） ,and the differences were statistically significant. The soldiers in Sudan spent more time in the Stroop color words test 1 [（67.76 ± 15.85） s] ,Stroop color words test 2 [ （28.15 ± 5.32） s] than those in the domestic （55.73 ± 15.50 ,23.05 ± 3.715） ,and the differences were statistically significant （P〈0.01） . The levels of IL‐6 [ （204.61 ± 94.98） ng/L] and TNF‐α[ （53.18 ± 2.69） pg/mL] of the soliders training intensely in South Sudan for 5 months were higher than those in the domestic [ （144.19 ± 72.40） ng/L and （45.01 ± 3.61） pg/mL , P〈0.05 ,respectively] .But the levels were in normal range. Conclusions The chronic military stress of the peace‐keeping soldiers in battlefield environment may influence the soliders’ executive function ,the levels of serum IL‐6 and TNF‐α.