不同程度阻塞性睡眠呼吸暂停低通气综合征男性患者血细胞参数、凝血指标分析

Analysis of blood cell parameter and coagulation indicator among male sufferers with obstructive sleep apnea hypopnea syndrome of varying degrees

目的探讨不同严重程度的阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的血细胞参数、凝血指标与病情的关系。方法选取2013-01—2015-08有睡眠呼吸暂停临床症状的男性,对130例OSAHS患者,根据呼吸暂停低通气指数(AHI)分为4组,测量各组的血细胞参数、凝血指标,比较多组间年龄、体质指数(BMI)、MPV、PDW、TT等参数。结果不同程度OSAHS血液的MPV、RDW、PDW、RBC、HCT等指标随疾病严重程度的增加而增加,PLT水平下降(P<0.05);随OSAHS严重程度的增加TT、APTT、PT有缩短的趋势,但仅APTT差异具有统计学意义(P<0.05)。随OSAHS患者严重程度增加发生心脑血管疾病的风险升高呈现上升趋势(χ2=9.663,P<0.05)。结论加强检测OSAHS患者细胞参数指标、凝血指标,在预测OSAHS患者发生心脑血管疾病风险方面有临床意义。

Objective To investigate the relationship between the blood cell parameters, blood coagulation indexes and the severity of obstructive sleep apnea hypopnea syndrome（OSAHS） of varying degrees.Methods 130 male suf- ferers with OSAHS from January 2013 to August 2015 were selected and divided into 4 groups according to the apnea hypopnea index （AHI）, and the blood cell parameters and blood coagulation indicators were measured.The parameters of age,body mass index （BMI）,MPV,PDW,and TT were measured.Results The levels of MPV,RDW,PDW, RBC, and HCT in OSAHS blood of varying degrees increased with the severity of the disease, and the PLT level de- creased（P 〈 0.05）.The time of thrombin（TT）, plasma prothrombin time （APTT）, and prothrombin time （PT） were signif- icantly shortened with the severity of OSAHS,but the difference of APTT was of statistical significance（P 〈 0.05）. With the increase of OSAHS severity, the risk of cardiovascular and cerebrovascular diseases was on the rise （X 2 = 9.663, P 〈 0.05）.Conclusion The strengthened detection of cell parameters and blood coagulation indicators in sufferers with OSAHS shows clinical significance in predicting the risk of cardiovascular and cerebrovascular diseases in sufferers with OSAHS.