Toll样受体与银屑病免疫发病机制的相关研究进展

Progress in The Study of Toll Like Receptors Expression in Psoriasis

Toll样受体(Toll-like receptors,TLRs)是一种新的跨膜受体,这是近年来新发现的一个分子家族式,在启动和调节天然免疫及诱导获得性免疫中起到关键作用。银屑病是一种病因还没有完全明确的T淋巴细胞介导的慢性皮肤免疫性疾病,免疫因素在其发病过程中亦起重要作用。Toll样受体作为免疫识别受体,能触发天然免疫和诱导获得性免疫,同时调节Toll样受体的表达可能与银屑病和其他疾病的病理生理相关。本文就TLRs在银屑病中的表达进行综述。

Toll like receptor （Toll like receptors （TLRs） is a new kind of transmembrane receptors, which is discovered in recent years in a molecular family, in initiating and regulating innate immune and induction plays a key role in the immunological. Psoriasis is a cause is not completely clear of the T lymphocyte mediated chronic cutaneous immunity disease, immune factors in the course of the disease and also important. Toll like receptor as immune recognition receptors can trigger innate immunity and induce immunity, and regulating the expression of Toll like receptor may produce the pathology of psoriasis and other diseases The expression of TLRs in psoria- sis was reviewed in this article.