巨幼细胞性贫血与难治性贫血的细胞形态学的鉴别

Identification of Cell Morphology Megaloblastic Anemia and Refractory Anemia Inner Mongolia Medical University Affiliated Hospital

目的通过观察分析细胞形态学在巨幼细胞性贫血与难治性贫血之间的区别,探讨其在鉴别两种贫血时的应用价值。方法收集我院2014年12月至2015年12月的巨幼细胞性贫血患者40例,设为巨幼细胞性贫血组;难治性贫血患者33例,设为难治性贫血组。分别对两组患者的外周血及骨髓的细胞形态进行回顾性分析。结果外周血细胞形态分析,巨幼细胞性贫血组有核红细胞PAS阳性率与难治性贫血组相比较,差异有统计学意义(P<0.05);骨髓细胞形态学分析,巨幼细胞性贫血组患者细胞形态检验结果中粒系病态、红系病态、淋巴样小巨核患者占比与难治性贫血组比较差异有统计学意义(P<0.05)。结论巨幼细胞性贫血与难治性贫血的细胞形态学检验结果在临床鉴别诊断上具有很高的应用价值。

Objective By analyzing megaloblastic anemia, refractory anemia with differences in cell morphology and explore its value in identifying two kinds of anemia. Method Our hospital megaloblastic anemia from December 2014 to December 2015 in 40 cases, to megaloblastic anemia group; 33 patients with refractory anemia, refractory anemia group set. Respectively peripheral blood and bone marrow cell morphology of the two groups of patients were analyzed retrospectively. Result Peripheral blood cell morphology analysis, megalohlastic anemia group nucleated red blood cells and PAS positive rate of refractory anemia with the group, the difference was statistically significant（ P 〈 0.05 ） ; bone marrow cell morphology analysis, megaloblastic anemia patients cell morphology test results in pathological myeloid, erythroid sick, lymphoid small proportion of nuclear giant patients with refractory anemia group, the difference was statistically significant（ P 〈 0.05）;the other test results data, the difference was not statistically significance（ P 〉 0.05 ）. Conlusion Megaloblastic anemia, re fractory anemia with cell morphology test results have high value in the clinical differential diagnosis.