摘要
The discovery of small non-coding RNAs - microRNA （miRNA）, short interfering RNA （siRNA） and PlWl- interacting RNA （piRNA） - represents one of the most exciting frontiers in biology specifically on the mechanism of gene regulation. In order to execute their functions, these small RNAs require physical interactions with their protein partners, the Argonaute （AGO） family proteins. Over the years, numerous studies have made tremendous progress on understanding the roles of AGO in gene silencing in various organisms. In this review, we summarize recent progress of AGO-mediated gene silencing and other cellular processes in which AGO proteins have been implicated with a particular focus on progress made in flies, humans and other model organisms as compliment.
The discovery of small non-coding RNAs - microRNA （miRNA）, short interfering RNA （siRNA） and PlWl- interacting RNA （piRNA） - represents one of the most exciting frontiers in biology specifically on the mechanism of gene regulation. In order to execute their functions, these small RNAs require physical interactions with their protein partners, the Argonaute （AGO） family proteins. Over the years, numerous studies have made tremendous progress on understanding the roles of AGO in gene silencing in various organisms. In this review, we summarize recent progress of AGO-mediated gene silencing and other cellular processes in which AGO proteins have been implicated with a particular focus on progress made in flies, humans and other model organisms as compliment.
基金
funded by the Fundamental Research Grant Scheme(203/PBIOLOGI/6711457)
two Universiti Sains Malaysia Research University grants(1001/PBIOLOGI/811274 and 1001/PBIOLOGI/ 811320)
funded by Science Fund grant(305/PBIOLOGI/ 613238)
funded by Yayasan Khazanah
